Evidence map›Paper›PMID 37353630›Full record

ArticleScientific reports2023

Resting heart rate and antisocial behaviour: a Mendelian randomisation study.

Lucy Karwatowska, Leonard Frach, Tabea Schoeler, Jorim J Tielbeek, Joseph Murray, Eco de Geus, Essi Viding, Jean-Baptiste Pingault

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Lucy KarwatowskaGreat Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK. lucy.karwatowska.18@ucl.ac.uk.ORCID 0000-0002-6519-5190
Leonard FrachDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.ORCID 0000-0001-6349-8772
Tabea SchoelerDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-4846-2741
Jorim J TielbeekDepartment of Complex Trait Genomics, VU University Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-6768-7359
Joseph MurrayPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.ORCID 0000-0002-5511-3454
Eco de GeusDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID 0000-0001-6022-2666
Essi VidingDevelopmental Risk & Resilience Unit, Division of Psychology & Language Sciences, University College London, London, UK.ORCID 0000-0001-8468-8874
Jean-Baptiste PingaultDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.ORCID 0000-0003-2557-4716
University College London · GBGGD Amsterdam · NLInstitute of Child Health · GRKing's College London · GBUniversidade Federal de Pelotas · BRUniversity of Lausanne · CHVrije Universiteit Amsterdam · NL

Funding

Biotechnology and Biological Sciences Research Council ES/P000347/1Wellcome Trust 218641/Z/19/Z
6 · The paper itself

Abstract

Observational studies frequently report phenotypic associations between low resting heart rate (RHR) and higher levels of antisocial behaviour (ASB), although it remains unclear whether this relationship reflects causality. To triangulate evidence, we conducted two-sample univariable Mendelian randomisation (MR), multivariable MR and linkage disequilibrium score regression (LDSC) analyses. Genetic data were accessed from published genome-wide association studies (GWAS) for RHR (n = 458,835) and ASB (n = 85,359) for the univariable analyses, along with a third GWAS for heart rate variability (HRV; n = 53,174) for all other analyses. Genome-wide significant (p < 5 × 10

Indexed as

Antisocial Personality DisorderGenome-Wide Association StudyHeart RateHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideRegression Analysis

Identifiers

PMID37353630
PMCPMC10290077
OpenAlexW4381800495

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.