Evidence map›Paper›PMID 37353587›Full record

ArticleCell biology and toxicology2023

Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells.

Giada Carta, Wanda van der Stel, Emma W J Scuric, Liliana Capinha, Johannes Delp, Susanne Hougaard Bennekou, Anna Forsby, Paul Walker, Marcel Leist, Bob van de Water and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giada CartaDivision of Molecular and Computational Toxicology, Vrije University Amsterdam, Amsterdam, the Netherlands. g.carta@vu.nl.ORCID http://orcid.org/0000-0001-8417-1242
Wanda van der StelDivision of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-8289-7189
Emma W J ScuricDivision of Molecular and Computational Toxicology, Vrije University Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2218-1231
Liliana CapinhaDivision of Molecular and Computational Toxicology, Vrije University Amsterdam, Amsterdam, the Netherlands.
Johannes DelpIn Vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp‑Zbinden Foundation, University of Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0003-3224-0677
Susanne Hougaard BennekouSection for Advice, Danish Patient Safety Authority, Randers, Denmark.ORCID http://orcid.org/0000-0001-6129-6966
Anna ForsbyDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6298-201X
Paul WalkerCyprotex Discovery Ltd., Alderley Park, Macclesfield, Cheshire, UK.ORCID http://orcid.org/0000-0002-7840-9709
Marcel LeistIn Vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp‑Zbinden Foundation, University of Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0002-3778-8693
Bob van de WaterDivision of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5839-2380
Paul JenningsDivision of Molecular and Computational Toxicology, Vrije University Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-6860-2898

Funding

EU-ToxRisk project funded by the European Union's Horizon 2020 681002
6 · The paper itself

Abstract

Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound's toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping changes in cellular behaviour to chemical insult, facilitates the characterisation of chemical hazard. In this study, we assessed the transcriptional landscape of mitochondrial impairment through the inhibition of the electron transport chain (ETC) in a human renal proximal tubular cell line (RPTEC/TERT1). We identified the unfolded protein response pathway (UPR), particularly the PERK/ATF4 branch as a common cellular response across ETC I, II and III inhibitions. This finding and the specific genes elaborated may aid the identification of mitochondrial liabilities of chemicals in both legacy data and prospective transcriptomic studies.

Indexed as

Epithelial CellsKidneyCell LineElectron TransportHumansProspective StudiesIn vitroMitochondriaRenalStress pathwayTranscriptomic

Identifiers

PMID37353587
PMCPMC10693540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.