Evidence map›Paper›PMID 37353482›Full record

ArticleNature communications2023

Molecular mechanism of phosphopeptide neoantigen immunogenicity.

Yury Patskovsky, Aswin Natarajan, Larysa Patskovska, Samantha Nyovanie, Bishnu Joshi, Benjamin Morin, Christine Brittsan, Olivia Huber, Samuel Gordon, Xavier Michelet and 11 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Solution mapping of MHC-I:TCR interactions using a minimalistic protein system.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
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  11. Review
  12. Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Yury Patskovsky *Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Aswin Natarajan *Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Larysa PatskovskaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Samantha NyovanieDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Bishnu JoshiAgenus, Lexington, MA, USA.
Benjamin MorinAgenus, Lexington, MA, USA.ORCID 0000-0001-6632-0320
Christine BrittsanAgenus, Lexington, MA, USA.
Olivia HuberAgenus, Lexington, MA, USA.
Samuel GordonAgenus, Lexington, MA, USA.
Xavier MicheletAgenus, Lexington, MA, USA.
Florian SchmitzbergerAgenus, Lexington, MA, USA.ORCID 0000-0001-9343-5561
Robert B SteinAgenus, Lexington, MA, USA.
Mark A FindeisAgenus, Lexington, MA, USA.ORCID 0000-0003-2875-4827
Andy HurwitzAgenus, Lexington, MA, USA.
Marc Van DijkAgenus, Lexington, MA, USA.ORCID 0000-0002-0190-7814
Eleni ChantzouraAgenus, Lexington, MA, USA.
Alvaro S YagueAgenus, Lexington, MA, USA.
Daniel Pollack SmithAgenus, Lexington, MA, USA.
Jennifer S BuellAgenus, Lexington, MA, USA.
Dennis UnderwoodAgenus, Lexington, MA, USA. dennis.underwood@agenusbio.com.ORCID 0000-0001-8307-9073
Michelle KrogsgaardDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Michelle.Krogsgaard@nyulangone.org.ORCID 0000-0001-5006-7981
Agenus (United States) · USNYU Langone Health · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
Project 4P50CA225450 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OSMAN, IMAN, WEBER, JEFFREY S · 2019 to 2025
$12.5M
TR&D4: Integrated pipeline for data analysisP41GM118302 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2017 to 2021
$8.5M
Mechanisms of impaired T-cell mechanosensing of melanoma antigensU01CA214354 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI KROGSGAARD, MICHELLE, ZHU, CHENG · 2017 to 2021
$3.9M
T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockadeR01CA243486 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KROGSGAARD, MICHELLE, ZHU, CHENG · 2020 to 2024
$3.5M
Mechanisms of initiation of T-cell signaling by the TCR-CD3 complexR01GM124489 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KROGSGAARD, MICHELLE · 2018 to 2021
$2.1M
Visualizing ligand-induced signal propagation in the TCR-signaling complexR01GM085586 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KROGSGAARD, MICHELLE · 2008 to 2014
$1.5M
Acquisition of a Cryoprobe for a 600 MHz NMR SpectrometerS10OD016343 · OD · NEW YORK UNIVERSITY · PI KROGSGAARD, MICHELLE, TRAASETH, NATHANIEL J. · 2014 to 2014
$360k
NCI NIH HHS P30 CA016087NCI NIH HHS P50 CA225450NCI NIH HHS R01 CA243486NCI NIH HHS U01 CA214354NIGMS NIH HHS P30 GM133893NIGMS NIH HHS P41 GM118302NIGMS NIH HHS R01 GM085586NIGMS NIH HHS R01 GM124489NIH HHS S10 OD016343
6 · The paper itself

Abstract

Altered protein phosphorylation in cancer cells often leads to surface presentation of phosphopeptide neoantigens. However, their role in cancer immunogenicity remains unclear. Here we describe a mechanism by which an HLA-B*0702-specific acute myeloid leukemia phosphoneoantigen, pMLL

Indexed as

PhosphopeptidesReceptors, Antigen, T-CellHumansProtein BindingPhosphopeptidesReceptors, Antigen, T-Cell

Identifiers

PMID37353482
PMCPMC10290117
OpenAlexW4381799882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.