Evidence map›Paper›PMID 37353407›Full record

ArticleTrends in molecular medicine2023

ELAC2 is a functional prostate cancer risk allele.

Steven Blinka, Rashmi Mishra, Andrew C Hsieh

Open access · greenAbstract read
In one paragraph

Article in Trends in molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Steven BlinkaHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; School of Medicine, University of Washington, Seattle, WA 98195, USA.
Rashmi MishraHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Andrew C HsiehHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; School of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address: ahsieh@fredhutch.org.
University of Washington · USFred Hutch Cancer Center · US

Funding

TRAINING IN CANCER BIOLOGY &TRANSPLANTATIONT32CA009515 · NCI · UNIVERSITY OF WASHINGTON · PI NANCY ELLEN DAVIDSON, Effie W Petersdorf · 1985 to 2026
$16.2M
Hormone signaling and translation control in advanced prostate cancerR37CA230617 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HSIEH, ANDREW CALEB · 2019 to 2025
$3.1M
Transcriptional-translational conflict in bladder epithelial homeostasis and cancerR01CA276308 · NCI · FRED HUTCHINSON CANCER CENTER · PI Andrew Caleb Hsieh · 2023 to 2026
$2.3M
Selective mRNA translation in developmental disordersR01GM135362 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERONJA, SLOBODAN, HSIEH, ANDREW CALEB · 2020 to 2023
$2.1M
NCI NIH HHS R01 CA276308NCI NIH HHS R37 CA230617NCI NIH HHS T32 CA009515NIGMS NIH HHS R01 GM135362
6 · The paper itself

Abstract

Stentenbach and colleagues have unveiled a functional role of a human germline mutation found in the ribonuclease (RNase) Z enzyme, ELAC2, in prostate cancer. Here, we discuss the importance of these findings in enhancing our understanding of how risk variants enable prostate cancer progression and the post-transcriptional mechanisms underlying oncogenesis.

Indexed as

Prostatic NeoplasmsAllelesGenetic Predisposition to DiseaseHumansMaleNeoplasm ProteinsELAC2 protein, humanNeoplasm ProteinsELAC2prostate cancertranslation controltRNA

Identifiers

PMID37353407
PMCPMC10527048
OpenAlexW4381487623

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.