Evidence map›Paper›PMID 37353230›Full record

ArticleBMJ (Clinical research ed.)2023

Associations between modest reductions in kidney function and adverse outcomes in young adults: retrospective, population based cohort study.

Junayd Hussain, Nicholas Grubic, Ayub Akbari, Mark Canney, Meghan J Elliott, Pietro Ravani, Peter Tanuseputro, Edward G Clark, Gregory L Hundemer, Tim Ramsay and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Prevalence of reduced eGFR in European adults using KDIGO and age-adapted eGFR thresholds.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  10. High measured GFR as a predictor of all-cause mortality and cardiovascular disease in a prospective non-diabetic population cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Junayd HussainSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Nicholas GrubicInstitute of Clinical Evaluative Sciences, Ottawa, ON, Canada.
Ayub AkbariDivision of Nephrology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
Mark CanneyDivision of Nephrology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
Meghan J ElliottDepartment of Medicine, University of Calgary, Calgary, AB, Canada.
Pietro RavaniDepartment of Medicine, University of Calgary, Calgary, AB, Canada.
Peter TanuseputroSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Edward G ClarkDivision of Nephrology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
Gregory L HundemerInstitute of Clinical Evaluative Sciences, Ottawa, ON, Canada.
Tim RamsaySchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Navdeep TangriDivision of Nephrology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Greg A KnollDivision of Nephrology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
Manish M SoodInstitute of Clinical Evaluative Sciences, Ottawa, ON, Canada msood@toh.ca.ORCID 0000-0002-9146-2344
Ottawa Hospital · CAUniversity of Ottawa · CAUniversity of Calgary · CAInstitute for Clinical Evaluative Sciences · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes.

designRetrospective, population based cohort study.

settingLinked healthcare administrative datasets in Ontario, Canada.

participantsAdult residents (18-65 years) with at least one outpatient eGFR value (categorized in 10 unit increments from 50 mL/min/1.73m

main outcome measureseGFRs and hazard ratios of composite adverse outcome (all cause mortality, any cardiovascular event, and kidney failure) stratified by age (18-39 years, 40-49 years, and 50-65 years), and relative to age specific eGFR referents (100-110 mL/min/1.73m

resultsFrom 1 January 2008 to 31 March 2021, among 8 703 871 adults (mean age 41.3 (standard deviation 13.6) years; mean index eGFR 104.2 mL/min/1.73m

conclusionsModest eGFR reductions were consistently associated with higher rates of adverse outcomes. Higher relative hazards were most prominent and occurred as early as eGFR <80 mL/min/1.73m

Indexed as

Renal Insufficiency, ChronicAdultCohort StudiesGlomerular Filtration RateHumansOntarioRetrospective StudiesYoung Adult

Identifiers

PMID37353230
PMCPMC10286512
OpenAlexW4381736506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.