ReviewNeurobiology of learning and memory2023
The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors.
Review in Neurobiology of learning and memory, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of neuromodulation interventions on the eating behaviors of patients with eating disorders compared to healthy controls, sham therapies, and other therapeutic approaches: A systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- The effects of rTMS over orbitofrontal cortex on cognitive functions in first-episode schizophrenia.Psychological medicine · 2026Trial
- The two-back task leads to activity in the left dorsolateral prefrontal cortex in schizophrenia patients with predominant negative symptoms: a fNIRS study and its implication for tDCS.Experimental brain research · 2024Trial
- Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion.Developmental cognitive neuroscience · 2026Article
- The role of the orbitofrontal cortex in smoking cue-reactivity in onset phase of smoking behavior, a fMRI study in adolescents.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Differences in other-directed emotion regulation tracks connectivity between amygdala and prefrontal regions during fairness decisions.bioRxiv : the preprint server for biology · 2026Article
- δ-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice.Neuroscience · 2026Article
- Neural Bases of Collective Social Behavior and Group Interactions across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Reward-related language processing of maternal speech in infants at different likelihood of ASD.Social cognitive and affective neuroscience · 2026Article
- A causal deep learning approach to identifying metabolic signatures of cognitive and functional decline in alzheimer's disease.Scientific reports · 2026Article
- Structurally constrained functional connectivity reveals efficient visuomotor decision-making mechanisms in action video gamers.Scientific reports · 2025Article
- Atypical brain function hierarchy in autism spectrum disorder: insights from a novel analytical approach based on neuronal oscillation pattern.European child & adolescent psychiatry · 2025Article
- Attachment as Prediction: Insights from Cognitive and Developmental Neuroscience.Current directions in psychological science · 2025Article
- Human ventromedial prefrontal cortex is necessary for prosocial motivation.Nature human behaviour · 2024Article
- Article
- The prefrontal cortex: from monkey to man.Brain : a journal of neurology · 2024Review
- Dissociable contributions of the hippocampus and orbitofrontal cortex to representing task space in a social context.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Characterizing the mechanisms of social connection.Neuron · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
The orbitofrontal cortex (OFC) is regarded as one of the core brain areas in a variety of value-based behaviors. Over the past two decades, tremendous knowledge about the OFC function was gained from studying the behaviors of single subjects. As a result, our previous understanding of the OFC's function of encoding decision variables, such as the value and identity of choices, has evolved to the idea that the OFC encodes a more complex representation of the task space as a cognitive map. Accumulating evidence also indicates that the OFC importantly contributes to behaviors in social contexts, especially those involved in cooperative interactions. However, it remains elusive how exactly OFC neurons contribute to social functions and how non-social and social behaviors are related to one another in the computations performed by OFC neurons. In this review, we aim to provide an integrated view of the OFC function across both social and non-social behavioral contexts. We propose that seemingly complex functions of the OFC may be explained by its role in providing a goal-directed cognitive map to guide a wide array of adaptive reward-based behaviors in both social and non-social domains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.