Evidence map›Paper›PMID 37353164›Full record

Trial reportPharmacology, biochemistry, and behavior2023

Subjective response to alcohol: Interactive effects of early life stress, parental risk for mood and substance use disorders, and drinking context.

Raquel Kosted, Dylan E Kirsch, Vanessa Le, Kim Fromme, Elizabeth T C Lippard

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pharmacology, biochemistry, and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04063384 (Subjective Response to Alcohol and Associated Neural Systems in Bipolar Disorder), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04063384 nacompletednot on this map

Subjective Response to Alcohol and Associated Neural Systems in Bipolar Disorder

TypeinterventionalSponsorUniversity of Texas at AustinRan2019 to 2024Enrolled60ConditionsBipolar Disorder, Alcohol Drinking, Alcohol Use DisorderArmsalcohol beverage, Placebo beverage
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Raquel KostedDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA.
Dylan E KirschDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Institute for Neuroscience, University of Texas, Austin, TX, USA.
Vanessa LeDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA.
Kim FrommeDepartment of Psychology, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA.
Elizabeth T C LippardDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA; Department of Psychology, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Institute for Neuroscience, University of Texas, Austin, TX, USA; Institute of Early Life Adversity Research, University of Texas, Austin, TX, USA. Electronic address: elizabeth.lippard@austin.utexas.edu.
The University of Texas at Austin · US

Funding

Genetic Mechanisms of Change in Trajectories of Drinking and Deviant BehaviorsR01AA020637 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI FROMME, KIM · 2012 to 2016
$2.3M
Subjective Response to Alcohol and Associated Neural Systems in Bipolar DisorderK01AA027573 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI LIPPARD, ELIZABETH THOMAS COX · 2019 to 2022
$716k
Dissecting Responses to Alcohol in Individuals with Familial Risk for Bipolar DisorderR21AA027884 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI LIPPARD, ELIZABETH THOMAS COX · 2020 to 2021
$416k
Ventral Prefrontal Network Connectivity and Alcohol Sensitivity in Bipolar Disorder and Typically Developing Young AdultsF31AA029005 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI KIRSCH, DYLAN E · 2022 to 2022
$20k
NIAAA NIH HHS F31 AA029005NIAAA NIH HHS K01 AA027573NIAAA NIH HHS R01 AA020637NIAAA NIH HHS R21 AA027884
6 · The paper itself

Abstract

Early life stress, specifically childhood maltreatment, and parental risk for mood and substance use disorders (SUDs) are associated with increased risk for alcohol use disorder (AUD). There is limited data on how these factors interact to contribute to alcohol-related outcomes. Prior work has suggested early life stress may increase sensitivity to psychostimulants and that subjective response to alcohol is heritable. It is unclear if early life stress alters sensitivity to alcohol and interacts with parental risk for mood/SUDs, which in turn may act as a risk factor for AUD. The current study uses within-subjects placebo-controlled alcohol administration methods to investigate the effects of childhood maltreatment on subjective response to alcohol in young adults with and without parental risk of mood/SUDs. Additionally, we explored interactions with drinking context (i.e., drinking in a bar vs. non-bar context). Within individuals with parental risk for mood/SUDs, there was a positive relation between total Childhood Trauma Questionnaire (CTQ) score and how drunk individuals reported feeling across both alcohol and placebo conditions (parental risk group-by-CTQ interaction p = .01; main effect of CTQ within individuals with parental risk for mood/SUDs p = .005). When exploring interactions with drinking context (bar vs. non-bar context), we observed a significant drinking context-by-parental risk-by-CTQ interaction (p = .03), with CTQ score positively associated with greater positive valence/positive arousal feelings in the parental risk group if they consumed their beverages in the bar context (p = .004) but not if they consumed their beverages in the non-bar context. Results suggest childhood maltreatment may contribute to variation in subjective response to the positive effects of alcohol-possibly mediated by alcohol cues and/or expectancies-in young adults with parental risk for mood/SUDs.

Indexed as

Adverse Childhood ExperiencesAlcoholismSubstance-Related DisordersAlcohol DrinkingHumansParentsYoung AdultAlcoholAlcohol expectanciesChildhood maltreatmentEarly life stressFamilial riskSensitivity

Identifiers

PMID37353164
PMCPMC10902860
OpenAlexW4381480359

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.