Evidence map›Paper›PMID 37352463›Full record

ArticleJournal of the American Chemical Society2023

Fungal P450 Deconstructs the 2,5-Diazabicyclo[2.2.2]octane Ring

Shuai Liu, Qiuyue Nie, Zhiwen Liu, Siddhant Patil, Xue Gao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shuai LiuDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States.
Qiuyue NieDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States.
Zhiwen LiuDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States.
Siddhant PatilDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States.
Xue GaoDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, United States.ORCID 0000-0003-3213-9704
Rice University · US

Funding

Undergraduate Summer Research ExperienceR35GM138207 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Xue Gao · 2020 to 2026
$2.4M
NIGMS NIH HHS R35 GM138207
6 · The paper itself

Abstract

Prenylated indole alkaloids (PIAs) possess great structural diversity and show biological activities. Despite significant efforts in investigating the biosynthetic mechanism, the key step in the transformation of 2,5-diazabicyclo[2.2.2]octane-containing PIAs into a distinct class of pentacyclic compounds remains unknown. Here, using a combination of gene deletion, heterologous expression, and biochemical characterization, we show that a unique fungal P450 enzyme CtdY catalyzes the cleavage of the amide bond in the 2,5-diazabicyclo[2.2.2]octane system, followed by a decarboxylation step to form the 6/5/5/6/6 pentacyclic ring in 21

Indexed as

Cytochrome P-450 Enzyme SystemOctanesIndole Alkaloidscitrinadin ACytochrome P-450 Enzyme SystemIndole AlkaloidsOctanes

Identifiers

PMID37352463
PMCPMC11025717
OpenAlexW4381839155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.