Evidence map›Paper›PMID 37352352›Full record

ArticleScience advances2023

Whole-body gene expression atlas of an adult metazoan.

Abbas Ghaddar, Erick Armingol, Chau Huynh, Louis Gevirtzman, Nathan E Lewis, Robert Waterston, Eyleen J O'Rourke

Abstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

  1. Article
  2. An atlas of thebioRxiv : the preprint server for biology · 2026
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  8. Starvation transforms signal encoding inbioRxiv : the preprint server for biology · 2026
    Article
  9. A pilot study for whole proteome tagging inbioRxiv : the preprint server for biology · 2026
    Article
  10. The SPARK complex forms the molecular basis of vertebrate fertilization.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. P-glycoproteins and amphids: a two-stage trajectory of ivermectin resistance in Caenorhabditis elegans.International journal for parasitology. Drugs and drug resistance · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Neuromodulation of swarming behavior inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abbas GhaddarDepartment of Biology, College of Arts and Sciences, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-8695-4694
Erick ArmingolBioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1546-9165
Chau HuynhDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.ORCID 0009-0006-4211-2811
Louis GevirtzmanDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.ORCID 0009-0001-5584-1101
Nathan E LewisDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-7700-3654
Robert WaterstonDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-5956-5215
Eyleen J O'RourkeDepartment of Biology, College of Arts and Sciences, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0003-0503-4181

Funding

Resource ProjectU41HG007355 · NHGRI · UNIVERSITY OF WASHINGTON · PI WATERSTON, ROBERT H · 2013 to 2021
$20.8M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Automated single-cell expression analysis in C. elegansR01GM072675 · NIGMS · UNIVERSITY OF WASHINGTON · PI WATERSTON, ROBERT H · 2005 to 2017
$7.1M
Unraveling the mammalian secretory pathway through systems biology and algorithm developmentR35GM119850 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEWIS, NATHAN ENOCH · 2016 to 2025
$4.3M
Gene expression and regulation in C. elegans with single cell resolutionR01HG010478 · NHGRI · UNIVERSITY OF WASHINGTON · PI WATERSTON, ROBERT H · 2019 to 2021
$1.5M
Conserved Mechanisms of Lipid Homeostasis in C. elegansR00DK087928 · NIDDK · UNIVERSITY OF VIRGINIA · PI O'ROURKE, EYLEEN JORGELINA · 2013 to 2015
$730k
Conserved Mechanisms of Lipid Homeostasis in C. elegansK99DK087928 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI O'ROURKE, EYLEEN JORGELINA · 2010 to 2011
$180k
NHGRI NIH HHS R01 HG010478NHGRI NIH HHS U41 HG007355NIDDK NIH HHS K99 DK087928NIDDK NIH HHS R00 DK087928NIGMS NIH HHS R01 GM072675NIGMS NIH HHS R35 GM119850NIH HHS P40 OD010440
6 · The paper itself

Abstract

Gene activity defines cell identity, drives intercellular communication, and underlies the functioning of multicellular organisms. We present the single-cell resolution atlas of gene activity of a fertile adult metazoan:

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsGene ExpressionGene Expression RegulationTranscription FactorsCaenorhabditis elegans ProteinsTranscription Factors

Identifiers

PMID37352352
PMCPMC10289653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.