Evidence map›Paper›PMID 37351955›Full record

ArticleJournal of animal science2023

Regulatory functional role of NLRP3 inflammasome during Mycoplasma hyopneumoniae infection in swine.

Yan Zhang, Bo Liu, Abdelrahman Said, Jinwen Xie, Fengrong Tian, Zongxi Cao, Zhe Chao, Feng Li, Xin Li, Shuguang Li and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Yan ZhangInstitute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou 571100, China.
Bo LiuShandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600, China.
Abdelrahman SaidGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Jinwen XieShandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600, China.
Fengrong TianShandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600, China.
Zongxi CaoInstitute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou 571100, China.
Zhe ChaoInstitute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou 571100, China.
Feng LiShandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600, China.
Xin LiXinjiang Agricultural University, Wulumuqi, Xinjiang, China.
Shuguang LiShandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600, China.
Hailong LiuInstitute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou 571100, China.
Wenxiu WangShandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600, China.
Binzhou Medical University · CNHaikou Experimental Station · CNHainan Provincial Academy of Agricultural Sciences · CNNational Research Centre · EGXinjiang Agricultural University · CN

Funding

Hainan Academy of Agricultural Sciences Key Laboratory Open Project HLP202107Hainan Province Livestock and Poultry Engineering Technology Research Center HLP201801Hainan Provincial Research Institute KYYS-2021-29National Natural Science Foundation of China 31560696Shandong Provincial Double Hundred Plan WST2018014Shandong Provincial Pig Industry Technology System SDAIT-08-13
6 · The paper itself

Abstract

Mycoplasma hyopneumoniae causes enzootic pneumonia, a highly contagious respiratory disease in swine that causes significant economic losses worldwide. It is unknown whether the nucleotide oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome regulates the immune response in swine during M. hyopneumoniae infection. The current study utilized an in vivo swine model of M. hyopneumoniae infection to investigate the regulatory functional role of the NLRP3 inflammasome during M. hyopneumoniae infection. Notable histopathological alterations were observed in M. hyopneumoniae-infected swine tissues, which were associated with an inflammatory response and disease progression. Swine M. hyopneumoniae infection was associated with an increase in the expression of the NLRP3 inflammasome, which stimulated pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin 18, and interleukin 1 beta (IL-1β). The impact of the NLRP3 inhibitor, MCC950 on NLRP3 and pro-inflammatory cytokines in M. hyopneumoniae-infected swine was examined to investigate the relationship between the NLRP3 inflammasome and M. hyopneumoniae infection. Taken together, our findings provide strong evidence that the NLRP3 inflammasome plays a critical regulatory functional role in M. hyopneumoniae infection in swine.

Indexed as

Mycoplasma hyopneumoniaeMycoplasma InfectionsSwine DiseasesAnimalsCytokinesInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinSwineCytokinesInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinMycoplasma hyopneumoniaeNLR family pyrin domain containing 3 (NLRP3) inflammasomepro-inflammatory cytokinesSwine

Identifiers

PMID37351955
PMCPMC10406421
OpenAlexW4381716674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.