Evidence map›Paper›PMID 37351807›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2024

Comparative analysis of upper aerodigestive tract and non-upper aerodigestive tract in NK/T-cell lymphoma.

Xiaohong Liu, Dedong Cao, Hui Liu, XiaoKang Ke, Xin Liu, Ximing Xu

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Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Prognostic value of the pre-treatment SUVmax ofCancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xiaohong LiuCancer Center, Renmin Hospital of Wuhan University, Hubei, 430060, People's Republic of China.ORCID http://orcid.org/0000-0002-9420-9635
Dedong CaoCancer Center, Renmin Hospital of Wuhan University, Hubei, 430060, People's Republic of China.ORCID http://orcid.org/0000-0002-5777-4176
Hui LiuDepartment of Hematology, Renmin Hospital of Wuhan University, Hubei, 430060, People's Republic of China.
XiaoKang KeDepartment of Pathology, Renmin Hospital of Wuhan University, Hubei, 430060, People's Republic of China.
Xin LiuCancer Center, Renmin Hospital of Wuhan University, Hubei, 430060, People's Republic of China.
Ximing XuCancer Center, Renmin Hospital of Wuhan University, Hubei, 430060, People's Republic of China. doctorxu120@aliyun.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNasal or extranasal natural killer/T-cell lymphoma (NKTCL) is a very rare aggressive lymphoma, but it is increasingly diagnosed. To evaluate some specificity by comparative analysis between primary upper aerodigestive tract (UAT) and non-upper aerodigestive tract (NUAT)NKTCL.

methodsA retrospective analysis was performed on NKTCL patients from January 2013 to November 2022 in our cancer center.

resultsThe majority of the lesions were UAT-NKTCL 70 cases (92.1%), the primary NUAT occurred in 6 cases. Patients in the UAT group were mainly in the early stage and in the low and medium risk, while those in the NUAT group were late stage and in high risk (p = 0.000). The expressions of CD3 and TIA-1 in UAT group were higher than those in NUAT group (p = 0.031, p = 0.003), while CD7 was dominant in NUAT group (p = 0.009). For early stage NKTCL, multivariate analysis suggested that gender and PINK score were independent factors affecting PFS and OS (p < 0.05). The 3 year OS rate in initial CR group was 90.1% versus 46.4% in non-CR group (p = 0.000). In advanced stage, KI67% and bone marrow involvement were independent factors affecting OS (p = 0.022, p = 0.038).

conclusionIt was difficult to distinguish between UAT and NUAT-NKTCL from histopathology. NUAT-NKTCL patients did have advanced stage and poor outcome. The prognostic value of PINK score and bone marrow involvement was proposed. We aimed to improve initial CR rates, as well as to find new predictive models to predict the whole population.

Indexed as

Lymphoma, Extranodal NK-T-CellHumansPrognosisRetrospective StudiesChemotherapyClinical featureNK/T-cell lymphomaPrognosisRadiotherapy

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.