ArticleActa parasitologica2023
Visceral Leishmaniasis Caused by Leishmania Tropica.
Article in Acta parasitologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Peptide-Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives.ChemMedChem · 2026Review
- Trends in Leishmaniasis: A 32-Year Review in an Endemic Area in the South of Madrid Region.Pathogens (Basel, Switzerland) · 2026Article
- Comparative histopathological and immunological analysis of LRV2-positive and LRV2-negative Leishmania tropica in a BALB/c mouse cutaneous leishmaniasis model.Parasitology research · 2025Article
- Antileishmanial Activities of Carvacrol Nanoencapsulate in Biopolymeric Nanoparticles.Chemistry & biodiversity · 2025Article
- Canine leishmaniasis caused by Leishmania Tropica in southeastern Iran: a case series study.Scientific reports · 2024Article
- Review of Leishmaniasis Treatment: Can We See the Forest through the Trees?Pharmacy (Basel, Switzerland) · 2024Review
- Knock, knock, knocking on EuropeCurrent research in parasitology & vector-borne diseases · 2023Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
purposeIn Turkey, the main causative agent of visceral leishmaniasis (VL) is Leishmania. infantum and the main causative agent of cutaneous leishmaniasis (CL) is Leishmania tropica. In this study, we aimed to discuss the possible mechanisms, clinical aspects, and threat of visceralizing L. tropica.
methodsThis study includes seven cases of VL caused by L. tropica.Five patients were male (71%) and four were adults (57%).
resultsAll the VL patients complained of fever and splenomegaly. Fatigue, pancytopenia, and hepatomegaly were present in six patients each (86%), while weight loss and gastrointestinal system (GIS) symptoms were present in 5 patients (71%).
conclusionsIn this study, we have evaluated seven cases of visceralized L. tropica (VLT) in the context of the changing leishmaniasis epidemiology in Turkey. We have evaluated the possible mechanisms of visceralization; inter- and intraspecies genetic exchange with all the old world leishmaniasis agents present in the region, stress induced by inappropriate use of drugs, and possible ongoing adaptation mechanisms of Leishmania spp. The threat posed by VLT is significant as L. tropica is the most widespread and most common cause of leishmaniasis in Turkey. We do not know the vectorial capacity of the sand flies for the transmission of VLT strains or if these strains are in circulation in Turkey. Future studies should be carried out to investigate these issues as the transition of L. tropica from a mild disease-causing agent to a mortal one poses a significant public health concern for Turkey and Europe.
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