Evidence map›Paper›PMID 37351756›Full record

ArticleAnnals of biomedical engineering2023

Model-Guided Design and Optimization of CPA Perfusion Protocols for Whole Organ Cryopreservation.

Zonghu Han, Joseph Sushil Rao, Srivasupradha Ramesh, Jan Hergesell, Bat-Erdene Namsrai, Michael L Etheridge, Erik B Finger, John C Bischof

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Lessons From Drug Discovery for Cryoprotective Agent Design: An AI-Oriented Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Zonghu HanDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA.
Joseph Sushil RaoDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Srivasupradha RameshDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA.
Jan HergesellInstitute for Multiphase Processes (IMP), Leibniz University, Hannover, Germany.
Bat-Erdene NamsraiDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Michael L EtheridgeDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA.
Erik B FingerDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
John C BischofDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA. bischof@umn.edu.ORCID http://orcid.org/0000-0001-6726-7111
University of Minnesota · USLeibniz University Hannover · DE

Funding

Organ banking for transplant—kidney cryopreservation by vitrification and novel nanowarming technologyR01DK117425 · NIDDK · UNIVERSITY OF MINNESOTA · PI JOHN C BISCHOF, Erik Brian Finger · 2018 to 2026
$4.9M
Cryopreservation and nanowarming enables whole liver banking for transplantation, cell therapy and biomedical researchR01DK132211 · NIDDK · UNIVERSITY OF MINNESOTA · PI JOHN C BISCHOF, Erik Brian Finger · 2023 to 2026
$2.6M
Breakthrough Tissue and Organ Preservation and Transplantation Using Scaled-Up Nanowarming TechnologyR01HL135046 · NHLBI · UNIVERSITY OF MINNESOTA · PI BISCHOF, JOHN C, FINGER, ERIK BRIAN · 2017 to 2020
$2.6M
NHLBI NIH HHS R01 HL135046NIDDK NIH HHS R01 DK117425NIDDK NIH HHS R01 DK132211NIH HHS NIH R01DK117425NIH HHS NIH R01DK132211NIH HHS NIH R01HL135046
6 · The paper itself

Abstract

Vitrification could enable long-term organ preservation, but only after loading high-concentration, potentially toxic cryoprotective agents (CPAs) by perfusion. In this paper, we combine a two-compartment Krogh cylinder model with a toxicity cost function to theoretically optimize the loading of CPA (VMP) in rat kidneys as a model system. First, based on kidney perfusion experiments, we systematically derived the parameters for a CPA transport loading model, including the following: V

Indexed as

CryopreservationVitrificationAnimalsCryoprotective AgentsOrgan PreservationPerfusionRatsCryoprotective AgentsCryoprotectantOrgan perfusion optimizationOrgan vitrificationToxicityTransport

Identifiers

PMID37351756
PMCPMC10518287
OpenAlexW4381715658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.