Evidence map›Paper›PMID 37351693›Full record

ArticleMolecular diversity2024

Extraction, isolation, synthesis, and biological evaluation of novel piperic acid derivatives for the treatment of Alzheimer's disease.

Jitendra Kumar, Gauri Shankar, Sunil Kumar, Jobin Thomas, Neha Singh, Saripella Srikrishna, Jitendra Satija, Sairam Krishnamurthy, Gyan Modi, Sunil Kumar Mishra

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Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jitendra KumarDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Gauri ShankarDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Sunil KumarDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Jobin ThomasCentre for Nanobiotechnology, Vellore Institute of Technology, Vellore, 632014, India.
Neha SinghDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Saripella SrikrishnaDepartment of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, 221 005, India.
Jitendra SatijaCentre for Nanobiotechnology, Vellore Institute of Technology, Vellore, 632014, India.
Sairam KrishnamurthyDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Gyan ModiDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Sunil Kumar MishraDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India. skmishra.phe@itbhu.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, we developed a series of piperic acid (PA) analogs with the aim of overcoming the limitations associated with the natural products for the management of Alzheimer's disease (AD). A comprehensive SAR study was performed to enhance cholinesterase inhibition of PA. The acetylcholinesterase inhibition and its kinetic data suggested 6j as the lead molecule (AChE IC

Indexed as

AcetylcholinesteraseAlzheimer DiseaseCholinesterase InhibitorsAnimalsAntioxidantsBlood-Brain BarrierDisease Models, AnimalFatty Acids, UnsaturatedHumansMaleMaze LearningMiceMolecular Docking SimulationNeuroprotective AgentsStructure-Activity RelationshipAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsFatty Acids, UnsaturatedNeuroprotective Agentspiperic acidAlzheimer’s diseaseAntioxidantsCholinesterase inhibitorsPiperic acidY-maze experiment

Identifiers

PMID37351693

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.