Evidence map›Paper›PMID 37351455›Full record

ArticleOpen forum infectious diseases2023

Prevalence of Cardiometabolic Disease Risk Factors in People With HIV Initiating Antiretroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda.

Willington Amutuhaire, Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Jean-Marc Schwarz, Mutebi Edrisa, Simon Dujanga, Robert A Salata, George A Yendewa

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Willington AmutuhaireDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Frank MulindwaMakerere University Infectious Diseases Institute, Kampala, Uganda.
Barbara CastelnuovoMakerere University Infectious Diseases Institute, Kampala, Uganda.
Nele BrusselaersGlobal Health Institute, Antwerp University, Antwerp, Belgium.ORCID https://orcid.org/0000-0003-0137-447X
Jean-Marc SchwarzSchool of Medicine, University of California San Francisco, San Francisco, California, USA.
Mutebi EdrisaDepartment of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Simon DujangaKisenyi Health Center, HIV Clinic, Kampala, Uganda.
Robert A SalataDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
George A YendewaDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-8474-1812

Funding

University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
HIV Co-infections in Uganda: TB, Cryptococcus, and Viral Hepatitis.D43TW009771 · FIC · JOHNS HOPKINS UNIVERSITY · PI CASTELNUOVO, BARBARA, KAMBUGU, ANDREW DDUNGU · 2014 to 2023
$3.3M
FIC NIH HHS D43 TW009343FIC NIH HHS D43 TW009771
6 · The paper itself

Abstract

Background: Cardiometabolic diseases are a leading cause of HIV-related morbidity and mortality, yet routine screening is not undertaken in high-burden countries. We aimed to assess the prevalence and risk factors of the metabolic syndrome (MetS) and its components in adult Ugandan people with HIV (PWH) initiating dolutegravir-based antiretroviral therapy (ART). Methods: We conducted a cross-sectional study using baseline sociodemographic and clinical data of PWH aged ≥18 years enrolled in the Glucose metabolism changes in Ugandan HIV patients on Dolutegravir (GLUMED) study from January to October 2021. MetS was defined as having ≥3 of the following: abdominal obesity, hypertension (HTN), hyperglycemia, elevated triglycerides, and low high-density lipoprotein cholesterol. Multiple logistic regression was used to assess associations between potential risk factors and MetS and its components. Results: Three hundred nine PWH were analyzed (100% ART-naïve, 59.2% female, median age 31 years, and median CD4 count 318 cells/mm Conclusions: Cardiometabolic risk factors were common in this young Ugandan cohort of PWH initiating dolutegravir-based ART, underscoring the need for programmatic implementation of surveillance and management of comorbidities in Uganda and similar settings.

Indexed as

ARTHIVmetabolic syndromeUganda

Identifiers

PMID37351455
PMCPMC10284103

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.