Evidence map›Paper›PMID 37350635›Full record

ArticleAnnals of clinical and translational neurology2023

Neurological diagnoses in hospitalized COVID-19 patients during the B.1.1.529 surge.

Carla Y Kim, Zomer Sardar, Biniyam A Ayele, Shannon Fleck-Derderian, Catherine E Barrett, Yifei Sun, Madison Clague, Holly A Hurst, Abhilasha Boruah, Jason Zucker and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Carla Y KimDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.ORCID 0000-0001-5714-7212
Zomer SardarDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.
Biniyam A AyeleDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.ORCID 0000-0002-7955-6030
Shannon Fleck-DerderianUnited States Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Catherine E BarrettUnited States Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Yifei SunDepartment of Biostatistics, Columbia University, New York, New York, USA.
Madison ClagueDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.
Holly A HurstDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.
Abhilasha BoruahDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.
Jason ZuckerDepartment of Infectious Disease, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.
Ryan MaddoxUnited States Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
James SejvarUnited States Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Kiran T ThakurDepartment of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, New York, USA.
NewYork–Presbyterian Hospital · USCenters for Disease Control and Prevention · USColumbia University · US

Funding

Columbia Partnership for Prevention and Control of HIV/AIDS Clinical Trials UnitUM1AI069470 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAGDALENA ELZBIETA SOBIESZCZYK · 2012 to 2026
$44.8M
Columbia Collaborative HIV/AIDS Clinical Trials UnitU01AI069470 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAMMER, SCOTT M · 2007 to 2011
$15.4M
NIAID NIH HHS U01 AI069470NIAID NIH HHS UM1 AI069470
6 · The paper itself

Abstract

objectiveEmerging variants and sublineages of SARS-CoV-2 have differing disease severity, transmissibility, and immune evasion. The neurological conditions associated with the original strain of SARS-CoV-2 are well established. Our study assessed the neurological presentations specific to hospitalized patients during the B.1.1.529 (Omicron) variant surge in New York City.

methodsA total of 178 cases with positive RT-PCR result within 6 weeks before admission, and subsequent development of select neurological conditions during the SARS-CoV-2 B.1.1.529 (Omicron) surge between December 1, 2021 and February 28, 2022, were included from 12,800 SARS-CoV-2-positive hospital admissions. Clinical data from acute hospitalizations were compared to findings of inpatient neurological cases with COVID-19 infections from the initial surge in NYC in the same hospital system.

resultsCompared to SARS-CoV-2 infections of the original strain, COVID-19 cases hospitalized during the Omicron surge (B.1.1.529) were associated with incidental and/or asymptomatic COVID-19 cases (96, 53.9%) and an increased incidence of pre-existing neurological and immunocompromising conditions. Encephalopathy, seizures, and stroke remained the most prevalent neurological conditions identified in hospitalized COVID-19 cases during the study period, reflecting a similar distribution of neurological presentations associated with the original strain.

interpretationIn our cohort of 178 admitted SARS-CoV-2-positive patients with select neurological conditions during the Omicron B.1.1.529 surge, 54% of COVID-19 cases were considered incidental and/or asymptomatic, and the identified neurological conditions resembled those associated with the original SARS-CoV-2 strain. Further studies characterizing neurological presentation in Omicron sublineages and other variants are warranted in an ongoing COVID-19 pandemic.

Indexed as

COVID-19StrokeHumansInpatientsPandemicsSARS-CoV-2

Identifiers

PMID37350635
PMCPMC10424653
OpenAlexW4381715808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.