ArticleTrials2023
Effectiveness of laparoscopic removal of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women (ESPriT2): protocol for a multi-centre randomised controlled trial.
Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Trial
- ESPriT1: the effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis for managing chronic pelvic pain in women: a randomised controlled feasibility trial.Reproduction & fertility · 2026Trial
- Endometriosis and Adenomyosis: Modern Concepts of Their Clinical Outcomes, Treatment, and Management.Journal of clinical medicine · 2024Review
- Endometriosis: Improvements and challenges in diagnosis and symptom management.Cell reports. Medicine · 2024Review
- Superficial Peritoneal Endometriosis Vaporization Using a COJournal of clinical medicine · 2024Article
- A bird-eye view of diaphragmatic endometriosis: current practices and future perspectives.Frontiers in medicine · 2024Review
- Holistic approaches to living well with endometriosis.F1000Research · 2024Review
- Comprehensive endometriosis care: a modern multimodal approach for the treatment of pelvic pain and endometriosis.Therapeutic advances in reproductive healthReview
- Improved Identification of Occult Peritoneal Endometriosis Using ABCt.JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
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Authors and funding
26 authors at 15 institutions in 4 countries.
Funding
Abstract
backgroundEndometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis is often achieved through diagnostic laparoscopy. However, when isolated superficial peritoneal endometriosis (SPE), the most common endometriosis subtype, is identified during laparoscopy, limited evidence exists to support the common decision to surgically remove it via excision or ablation. Improved understanding of the impact of surgical removal of isolated SPE for the management of chronic pelvic pain in women is required. Here, we describe our protocol for a multi-centre trial to determine the effectiveness of surgical removal of isolated SPE for the management of endometriosis-associated pain.
methodsWe plan to undertake a multi-centre participant-blind parallel-group randomised controlled clinical and cost-effectiveness trial with internal pilot. We plan to randomise 400 participants from up to 70 National Health Service Hospitals in the UK. Participants with chronic pelvic pain awaiting diagnostic laparoscopy for suspected endometriosis will be consented by the clinical research team. If isolated SPE is identified at laparoscopy, and deep or ovarian endometriosis is not seen, participants will be randomised intraoperatively (1:1) to surgical removal (by excision or ablation or both, according to surgeons' preference) versus diagnostic laparoscopy alone. Randomisation with block-stratification will be used. Participants will be given a diagnosis but will not be informed of the procedure they received until 12 months post-randomisation, unless required. Post-operative medical treatment will be according to participants' preference. Participants will be asked to complete validated pain and quality of life questionnaires at 3, 6 and 12 months after randomisation. Our primary outcome is the pain domain of the Endometriosis Health Profile-30 (EHP-30), via a between randomised group comparison of adjusted means at 12 months. Assuming a standard deviation of 22 points around the pain score, 90% power, 5% significance and 20% missing data, 400 participants are required to be randomised to detect an 8-point pain score difference. DISCUSSION: This trial aims to provide high quality evidence of the clinical and cost-effectiveness of surgical removal of isolated SPE.
trial registrationISRCTN registry ISRCTN27244948. Registered 6 April 2021.
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