Evidence map›Paper›PMID 37349670›Full record

ArticleObesity surgery2023

Changes in Oesophageal Transit, Macro-Reflux Events, and Gastric Emptying Correlate with Improvements in Gastro-Intestinal Symptoms and Food Tolerance Early Post Sleeve Gastrectomy.

Anagi C Wickremasinghe, Yazmin Johari, Helen Yue, Cheryl Laurie, Kalai Shaw, Julie Playfair, Paul Beech, Geoffrey Hebbard, Kenneth S Yap, Wendy Brown and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Anagi C WickremasingheMonash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia. anagi.wickremasinghe@monash.edu.ORCID 0000-0001-9876-7792
Yazmin JohariMonash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.
Helen YueDepartment of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia.
Cheryl LaurieMonash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.
Kalai ShawMonash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.
Julie PlayfairMonash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.
Paul BeechDepartment of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia.
Geoffrey HebbardDepartment of Gastroenterology, Royal Melbourne Hospital and University of Melbourne, Parkville, VIC, 3050, Australia.
Kenneth S YapDepartment of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia.
Wendy BrownMonash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.
Paul BurtonMonash University Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.
The Alfred Hospital · AUMonash University · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere are significant alterations in gastro-intestinal function, food tolerance, and symptoms following sleeve gastrectomy (SG). These substantially change over the first year, but it is unclear what the underlying physiological basis for these changes is. We examined changes in oesophageal transit and gastric emptying and how these correlate with changes in gastro-intestinal symptoms and food tolerance. MATERIAL AND

methodsPost-SG patients undertook protocolised nuclear scintigraphy imaging along with a clinical questionnaire at 6 weeks, 6 months, and 12 months.

resultsThirteen patients were studied: mean age (44.8 ± 8.5 years), 76.9% females, pre-operative BMI (46.9 ± 6.7 kg/m2). Post-operative %TWL was 11.9 ± 5.1% (6 weeks) and 32.2 ± 10.1% (12 months), p-value < 0.0001. There was a substantial increase of meal within the proximal stomach; 22.3% (IQR 12%) (6 weeks) vs. 34.2% (IQR 19.7%) (12 months), p = 0.038. Hyper-accelerated transit into the small bowel decreased from 6 weeks 49.6% (IQR 10.8%) to 42.7% (IQR 20.5%) 12 months, p = 0.022. Gastric emptying half-time increased from 6 weeks 19 (IQR 8.5) to 12 months 27 (IQR 11.5) min, p = 0.027. The incidence of deglutitive reflux of semi-solids decreased over time; 46.2% (6 weeks) vs. 18.2% (12 months), p-value < 0.0001. Reflux score of 10.6 ± 7.6 at 6 weeks vs. 3.5 ± 4.4 at 12 months, (p = 0.049) and regurgitation score of 9.9 ± 3.3 at 6 weeks vs. 6.5 ± 1.7, p = 0.021 significantly reduced.

conclusionsThese data demonstrate that there is an increase in the capacity of the proximal gastric sleeve to accommodate substrate over the first year. Gastric emptying remains rapid but reduce over time, correlating with improved food tolerance and reduced reflux symptoms. This is likely the physiological basis for the changes in symptoms and food tolerance observed early post-SG.

Indexed as

Gastroesophageal RefluxObesity, MorbidAdultFemaleGastrectomyGastric EmptyingHumansMaleMiddle AgedBariatric outcomeBariatric surgery mechanismClinical trialFood toleranceGastric emptyingGastrointestinal symptomsNuclear scintigraphyPhysiologyRefluxSleeve

Identifiers

PMID37349670
PMCPMC10345052
OpenAlexW4381716691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.