Evidence map›Paper›PMID 37349602›Full record

ArticleNeurocritical care2024

Cognitive Motor Dissociation: Gap Analysis and Future Directions.

Jan Claassen, Daniel Kondziella, Ayham Alkhachroum, Michael Diringer, Brian L Edlow, Joseph J Fins, Olivia Gosseries, Yousef Hannawi, Benjamin Rohaut, Caroline Schnakers and 4 more

Open access · greenAbstract read
In one paragraph

Article in Neurocritical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. The Gray Zone of Consciousness: Cognitive Motor Dissociation.Current neurology and neuroscience reports · 2025
    Review
  17. Article
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 4 countries.

Jan ClaassenDepartment of Neurology, Neurological Institute, Columbia University Irving Medical Center, NewYork Presbyterian Hospital, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA. jc1439@columbia.edu.ORCID 0000-0002-5893-8531
Daniel KondziellaDepartment of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Ayham AlkhachroumUniversity of Miami, Miami, FL, USA.
Michael DiringerDepartment of Neurology, Washington University, St. Louis, MO, USA.
Brian L EdlowDepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, 02114, USA.
Joseph J FinsDivision of Medical Ethics, Department of Medicine, Weill Cornell Medical College, NewYork Presbyterian Hospital, New York, NY, 10032, USA.
Olivia GosseriesComa Science Group, GIGA Consciousness, University of Liege, Liege, Belgium.
Yousef HannawiDivision of Cerebrovascular Diseases and Neurocritical Care, Department of Neurology, The Ohio State University, Columbus, OH, USA.
Benjamin RohautSorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP) - Pitié Salpêtrière, Paris, France.
Caroline SchnakersCasa Colina Hospital and Centers for Healthcare, Pomona, CA, USA.
Robert D StevensDepartment of Anesthesiology and Critical Care Medicine, Neurology, and Radiology, School of Medicine, Secondary Appointment in Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Aurore ThibautComa Science Group, GIGA Consciousness, University of Liege, Liege, Belgium.
Martin MontiDepartment of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
Curing Coma Campaign, and Its Contributing Collaborators
University of Liège · BECasa Colina Centers for Rehabilitation · USColumbia University Irving Medical Center · USJohns Hopkins University · USMassachusetts General Hospital · USNewYork–Presbyterian Hospital · USSorbonne Université · FRThe Ohio State University · USUniversity of California, Los Angeles · USUniversity of Copenhagen · DKUniversity of Miami · USWashington University in St. Louis · US

Funding

Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
NIDUS III: Advanced-Stage Development and Utilization of the NIDUS Research Infrastructure to Advance Interdisciplinary Aging Research inDeliriumR33AG071744 · NIA · JOHNS HOPKINS UNIVERSITY · PI John W. Devlin, Esther Seunghee Oh · 2021 to 2026
$4.7M
RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGeR01NS106014 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2023
$3.6M
MUSICA - MUsic and Speech Induced Cerebral ActivationK23NS126577 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Ayham Alkhachroum · 2022 to 2026
$910k
Cognitive Restoration: Neuroethics and Disability RightsRF1MH121378 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI FINS, JOSEPH J. · 2019 to 2019
$858k
COVERT– COvert Volitional Eye Response TestR21NS128326 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALKHACHROUM, AYHAM, CLAASSEN, JAN · 2022 to 2023
$428k
BAsIC - Brain-computer-interface practical Application in the Intensive Care unit: a pilot studyR03NS112760 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2020
$162k
NCATS NIH HHS UL1 TR002736NIA NIH HHS R33 AG071744NIMH NIH HHS RF1 MH121378NINDS NIH HHS K23 NS126577NINDS NIH HHS NS106014NINDS NIH HHS NS112760NINDS NIH HHS NS126577NINDS NIH HHS NS128326NINDS NIH HHS R01 NS106014NINDS NIH HHS R03 NS112760NINDS NIH HHS R21 NS128326
6 · The paper itself

Abstract

backgroundPatients with disorders of consciousness who are behaviorally unresponsive may demonstrate volitional brain responses to motor imagery or motor commands detectable on functional magnetic resonance imaging or electroencephalography. This state of cognitive motor dissociation (CMD) may have prognostic significance.

methodsThe Neurocritical Care Society's Curing Coma Campaign identified an international group of experts who convened in a series of monthly online meetings between September 2021 and April 2023 to examine the science of CMD and identify key knowledge gaps and unmet needs.

resultsThe group identified major knowledge gaps in CMD research: (1) lack of information about patient experiences and caregiver accounts of CMD, (2) limited epidemiological data on CMD, (3) uncertainty about underlying mechanisms of CMD, (4) methodological variability that limits testing of CMD as a biomarker for prognostication and treatment trials, (5) educational gaps for health care personnel about the incidence and potential prognostic relevance of CMD, and (6) challenges related to identification of patients with CMD who may be able to communicate using brain-computer interfaces.

conclusionsTo improve the management of patients with disorders of consciousness, research efforts should address these mechanistic, epidemiological, bioengineering, and educational gaps to enable large-scale implementation of CMD assessment in clinical practice.

Indexed as

Brain InjuriesConsciousness DisordersBrainConsciousnessHumansMagnetic Resonance ImagingAcute brain injuryCognitive motor dissociationComaConsciousnessCovert consciousnessCuring Coma CampaignOutcomePrognosticationVegetative state

Identifiers

PMID37349602
PMCPMC12517403
OpenAlexW4381716260

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.