Evidence map›Paper›PMID 37349473›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023

PET imaging of dopamine transporters and D2/D3 receptors in female monkeys: effects of chronic cocaine self-administration.

Mia I Allen, Angela N Duke, Susan H Nader, Adrienne Adler-Neal, Kiran K Solingapuram Sai, Beth A Reboussin, H Donald Gage, Ronald J Voll, Akiva Mintz, Mark M Goodman and 1 more

Open access · greenAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. The use ofFrontiers in cell and developmental biology · 2026
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  14. A non-human primate model of cocaine addiction: interpreting associations with increased vs. decreased dopamine function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mia I AllenDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Angela N DukeDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Susan H NaderDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Adrienne Adler-NealDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Kiran K Solingapuram SaiDepartment of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Beth A ReboussinDepartment of Biostatistics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
H Donald GageDepartment of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Ronald J VollDepartment of Radiology, Emory University School of Medicine, 1515 Dickey Drive, Atlanta, GA, 30322, USA.
Akiva MintzDepartment of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Mark M GoodmanDepartment of Radiology, Emory University School of Medicine, 1515 Dickey Drive, Atlanta, GA, 30322, USA.ORCID 0000-0002-3438-1185
Michael A NaderDepartment of Physiology & Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA. mnader@wakehealth.edu.
Wake Forest University · USEmory University · US

Funding

Mechanisms Mediating Cocaine Abuse in Socially Housed Female and Male MonkeysR01DA017763 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael A Nader · 2004 to 2026
$9.8M
The Neurobiology of Drug AbuseT32DA041349 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SARA RAULERSON JONES · 2017 to 2026
$1.8M
The effect of ethanol self-administration on cocaine reinforcement in male and female monkeysF31DA060614 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ROUGH, MIA ISABEL · 2024 to 2025
$86k
NIDA NIH HHS DA017763NIDA NIH HHS F31 DA060614NIDA NIH HHS R01 DA017763NIDA NIH HHS T32 DA041349
6 · The paper itself

Abstract

Brain imaging studies using positron emission tomography (PET) have shown that long-term cocaine use is associated with lower levels of dopamine (DA) D2/D3 receptors (D2/D3R); less consistent are the effects on DA transporter (DAT) availability. However, most studies have been conducted in male subjects (humans, monkeys, rodents). In this study, we used PET imaging in nine drug-naïve female cynomolgus monkeys to determine if baseline measures of DAT, with [

Indexed as

CocainePositron-Emission TomographyAnimalsDopamine Plasma Membrane Transport ProteinsFemaleHaplorhiniRacloprideReceptors, Dopamine D3Self AdministrationCocaineDopamine Plasma Membrane Transport ProteinsRacloprideReceptors, Dopamine D3

Identifiers

PMID37349473
PMCPMC10425413
OpenAlexW4381615428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.