ArticleNature communications2023
A 13-million turnover-number anionic Ir-catalyst for a selective industrial route to chiral nicotine.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Article
- Bulky alkali metal cations enabled highly efficient iridium-catalyzed asymmetric hydrogenation for C-N axial chiralityChemical science · 2026Article
- Efficient synthesis of chiral vicinal diamines with four contiguous stereocenters via sequential dynamic kinetic resolution of 2,3-diamino-1,4-diketones.Nature communications · 2026Article
- Scalable and sustainable synthesis of chiral amines by biocatalysis.Communications chemistry · 2025Article
- Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C-H bonds with TON over 1000000.Nature communications · 2025Article
- A Multimetal Approach for the Reticulation of Iridium into Metal-Organic Framework Building Units.Journal of the American Chemical Society · 2024Article
- Asymmetric Hydrogenation of Ketones by Simple Alkane-Diyl-Based Ir(P,N,O) Catalysts: A Comparative Study.Molecules (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Developing catalysts with both useful enantioselectivities and million turnover numbers (TONs) for asymmetric hydrogenation of ketones is attractive for industrial production of high-value bioactive chiral entities but remains a challenging. Herein, we report an ultra-efficient anionic Ir-catalyst integrated with the concept of multidentate ligation for asymmetric hydrogenation of ketones. Biocatalysis-like efficacy of up to 99% ee (enantiomeric excess), 13,425,000 TON (turnover number) and 224 s
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.