Evidence map›Paper›PMID 37349122›Full record

SynthesisRMD open2023

Characterisation of prodromal and very early psoriatic arthritis: a systematic literature review informing a EULAR taskforce.

Gabriele De Marco, Alen Zabotti, Xenofon Baraliakos, Annamaria Iagnocco, Daniel Aletaha, Paulo Gisondi, Jenny Emmel, Josef S Smolen, Dennis G McGonagle, Laure Gossec

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in RMD open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

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  18. Early psoriatic arthritis: when is the right time to start advanced therapy?Therapeutic advances in musculoskeletal disease · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Gabriele De Marco *Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.ORCID 0000-0003-2406-161X
Alen Zabotti *Department of Medicine, University of Udine, Rheumatology Institute, c/o Azienda Sanitaria, Udine, Italy zabottialen@gmail.com.ORCID 0000-0002-0573-464X
Xenofon BaraliakosRheumazentrum Ruhrgebiet, Ruhr University Bochum, Herne, Germany.ORCID 0000-0002-9475-9362
Annamaria IagnoccoAcademic Rheumatology Centre, Ospedale Mauriziano - Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Turin, Italy.ORCID 0000-0001-5592-724X
Daniel AletahaDivision of Rheumatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2108-0030
Paulo GisondiSection of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.
Jenny EmmelMedical Education, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Josef S SmolenMedicine 3, Division of Rheumatology, Medizinische Universitat Wien, Wien, Austria.
Dennis G McGonagle *Chapel Allerton Hospital, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, NIHR Leeds Biomedical Research Centre, Leeds, UK.
Laure Gossec *INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, INSERM, Sorbonne Universite, Paris, France.ORCID 0000-0002-4528-310X
Medical University of Vienna · ATUniversity of Leeds · GBA. O. Ordine Mauriziano di Torino · ITInserm · FRLeeds Teaching Hospitals NHS Trust · GBRheumazentrum Ruhrgebiet · DEUniversity of Udine · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying subjects at risk of imminent psoriatic arthritis (PsA) would allow these subjects to participate in therapeutic interventions to delay or prevent PsA development.

methodsA systematic literature review (SLR) was conducted in 2021 in Medline, Embase, PubMed, Central databases and international congress abstracts (PROSPERO CRD42022255102). All articles reporting the characteristics of patients transitioning from psoriasis (PsO) to PsA and from undifferentiated arthritis (UA) to PsA were included. Clinical and imaging characteristics were collated before PsA onset and at time of PsA diagnosis.

resultsEighteen of 23 576 references evaluated for PsO/PsA transition were analysed; 14 were cohort studies, 2 case-control studies. Two SLRs were used to enrich the project but were not analysed per se. Of 7873 references focusing on UA to PsA, 3 studies were included. Meta-analysis was not possible due to excessive data heterogeneity. Patients with PsO who developed PsA often reported joint pain, joint tenderness and functional limitations. Arthralgia (PsO, n=669; incident PsA, n=99) was associated with subsequent PsA development. On imaging, subclinical enthesopathy (PsO=325; Incident PsA=39) appeared linked to later PsA development. At the time of PsA onset (incident PsA, N=214), peripheral arthritis, mainly oligo-arthritis (ie, the mean number of swollen joints ranged from 1.5 to 3.2), was the most frequent pattern of clinical presentation.

conclusionsJoint pain, arthralgia and entheseal involvement detected by imaging were frequent in individuals with PsO at risk for imminent PsA. Very early PsA was mainly oligoarticular. This review informed a EULAR taskforce on transition to PsA.

Indexed as

Arthritis, PsoriaticEnthesopathyPsoriasisArthralgiaCase-Control StudiesHumansarthritisarthritis, psoriaticinflammation

Identifiers

PMID37349122
PMCPMC10314670
OpenAlexW4381715475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.