Evidence map›Paper›PMID 37348970›Full record

ArticleAJNR. American journal of neuroradiology2023

T2-FLAIR Mismatch Sign in Pediatric Low-Grade Glioma.

M W Wagner, L Nobre, K Namdar, F Khalvati, U Tabori, C Hawkins, B B Ertl-Wagner

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Angiocentric glioma: a single center experience and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Pediatric-type diffuse low-grade glioma with T2-FLAIR mismatch sign: a case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Advances in diffuse glial tumors diagnosis.Arquivos de neuro-psiquiatria · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 6 countries.

M W WagnerFrom the Division of Neuroradiology (M.W.W., F.K., B.B.E.-W.), Department of Diagnostic Imaging m.w.wagner@me.com.ORCID 0000-0001-6501-839X
L NobreDepartment of Neurooncology (L.N., U.T.).ORCID 0000-0001-5900-977X
K NamdarDepartment of Medical Imaging (M.W.W., K.N., F.K., B.B.E.-W.).ORCID 0000-0003-0497-6206
F KhalvatiFrom the Division of Neuroradiology (M.W.W., F.K., B.B.E.-W.), Department of Diagnostic Imaging.ORCID 0000-0001-5616-8660
U TaboriDepartment of Neurooncology (L.N., U.T.).ORCID 0000-0002-5019-2683
C HawkinsDepartment of Paediatric Laboratory Medicine (C.H.), Division of Pathology, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada.ORCID 0000-0003-2618-4402
B B Ertl-WagnerFrom the Division of Neuroradiology (M.W.W., F.K., B.B.E.-W.), Department of Diagnostic Imaging.ORCID 0000-0002-7896-7049
's Heeren Loo · NLUniversity of Toronto · CAMental Health Research Canada · CASickKids Foundation · CAUniversity Hospital Augsburg · DE

Funding

CIHR 159805
6 · The paper itself

Abstract

background and purposeNo qualitative imaging feature currently predicts molecular alterations of pediatric low-grade gliomas with high sensitivity or specificity. The T2-FLAIR mismatch sign predicts MATERIALS AND

methodsPretreatment MR images acquired between January 2001 and August 2018 in pediatric patients with pediatric low-grade gliomas were retrospectively identified. Inclusion criteria were the following: 1) 0-18 years of age, 2) availability of molecular information in histopathologically confirmed cases, and 3) availability of preoperative brain MR imaging with non-motion-degraded T2-weighted and FLAIR sequences. Spinal cord tumors were excluded.

resultsThree hundred forty-nine patients were included (187 boys; mean age, 8.7 [SD, 4.8] years; range, 0.5-17.7 years).

conclusionsThe T2-FLAIR mismatch sign was not observed in the common molecular alterations,

Indexed as

AstrocytomaBrain NeoplasmsGliomaAdultChildChild, PreschoolHumansIsocitrate DehydrogenaseMagnetic Resonance ImagingMaleMutationProto-Oncogene Proteins B-rafRetrospective StudiesIsocitrate DehydrogenaseProto-Oncogene Proteins B-raf

Identifiers

PMID37348970
PMCPMC10337621
OpenAlexW4381613675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.