ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023
Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- Pleural fluid agitation for improving the microbiologic diagnostic yield in pleural infection: a feasibility study.Respiratory research · 2025Trial
- Microbial Detection in Community-Acquired Pleural Space Infections Using the BIOFIRE Joint Infection Panel and Individual Polymerase Chain Reaction Assays.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Article
- Management of Pediatric Parapneumonic Pleural Effusion: Interventional Versus Conservative Approaches in an 11-Year Retrospective Cohort.Journal of clinical medicine · 2026Article
- Cadherin-11 serves as a novel receptor for Fusobacterium nucleatum adhesin FadA to exacerbate pulmonary inflammation.PLoS pathogens · 2026Article
- Odontogenic Brain Abscess in a Hereditary Haemorrhagic Telangiectasia (HHT) Patient: Case Report with a Comprehensive Literature Review.Tropical medicine and infectious disease · 2026Article
- What is new in pleural infections?Breathe (Sheffield, England) · 2026Review
- Comparison of clinical characteristics and outcomes between patients with complicated pleural infection caused byPleura and peritoneum · 2025Article
- The role of molecular diagnostics in pleural empyema: insights from a 4-year analysis of microbial trends and antimicrobial use.Journal of medical microbiology · 2025Article
- Positive selection at core genes may underlie niche adaptation in Fusobacterium animalis.Gut pathogens · 2025Article
- Bacterial translocation signatures and subgingival microbiome in individuals with periodontitis.Clinical oral investigations · 2025Article
- Review
- Diversity in the composition of pleural cavity and oral cavity microbiota in different bacterial empyema.Frontiers in microbiology · 2025Article
- Oral Health Related Factors Predicting Severe COVID-19 Disease in Elderly Swedes.Journal of oral rehabilitation · 2025Article
- Abscesses of the spine and iliac fossa caused by infection with the opportunistic bacteriumIDCases · 2025Article
- Pleural Infection: Contemporary Microbiology Completing the Picture.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Pleural space infection microbiology as assessed using a clinical sequencing-based assay:Journal of clinical microbiology · 2024Article
- Fusobacterium nucleatum-Induced Empyema Masquerading as Lung Cancer: A Diagnostic Challenge.Cureus · 2024Article
- Augmented pathogen detection in brain abscess using metagenomic next-generation sequencing: a retrospective cohort study.Microbiology spectrum · 2024Article
- Article
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Authors and funding
17 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany community-acquired pleural infections are caused by facultative and anaerobic bacteria from the human oral microbiota. The epidemiology, clinical characteristics, pathogenesis, and etiology of such infections are little studied. The aim of the present prospective multicenter cohort study was to provide a thorough microbiological and clinical characterization of such oral-type pleural infections and to improve our understanding of the underlying etiology and associated risk factors.
methodsOver a 2-year period, we included 77 patients with community-acquired pleural infection, whereof 63 (82%) represented oral-type pleural infections. Clinical and anamnestic data were systematically collected, and patients were offered a dental assessment by an oral surgeon. Microbial characterizations were done using next-generation sequencing. Obtained bacterial profiles were compared with microbiology data from previous investigations on odontogenic infections, bacteremia after extraction of infected teeth, and community-acquired brain abscesses.
resultsFrom the oral-type pleural infections, we made 267 bacterial identifications representing 89 different species. Streptococcus intermedius and/or Fusobacterium nucleatum were identified as a dominant component in all infections. We found a high prevalence of dental infections among patients with oral-type pleural infection and demonstrate substantial similarities between the microbiology of such pleural infections and that of odontogenic infections, odontogenic bacteremia, and community-acquired brain abscesses.
conclusionsOral-type pleural infection is the most common type of community-acquired pleural infection. Current evidence supports hematogenous seeding of bacteria from a dental focus as the most important underlying etiology. Streptococcus intermedius and Fusobacterium nucleatum most likely represent key pathogens necessary for establishing the infection.
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