Evidence map›Paper›PMID 37348639›Full record

ArticleEnvironmental research2023

Longitudinal association of prepubertal urinary phthalate metabolite concentrations with pubertal progression among a cohort of boys.

J S Burns, J R Bather, O Sergeyev, M M Lee, S A Korrick, S Sokolov, S Kovalev, H M Koch, A T Lebedev, L Mínguez-Alarcón and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

J S BurnsEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, 14th Floor, Boston, MA, 02115, USA. Electronic address: jburns@hsph.harvard.edu.
J R BatherDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 2, 4th Floor, Boston, MA, 02115, USA.
O SergeyevGroup of Epigenetic Epidemiology, Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskye Gory, House 1, Building 40, Room 322, 119992, Moscow, Russia.
M M LeeNemours Children's Health/Sidney Kimmel Medical School, Jefferson University, 1600 Rockland Road, Wilmington, DE, USA.
S A KorrickEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, 14th Floor, Boston, MA, 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 3rd Floor West, Boston, MA, 02215, USA.
S SokolovChemistry Department, Lomonosov Moscow State University, Moscow, 119991, Leninskie Gory 1/3, Russia.
S KovalevChemistry Department, Lomonosov Moscow State University, Moscow, 119991, Leninskie Gory 1/3, Russia.
H M KochInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance - Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
A T LebedevChemistry Department, Lomonosov Moscow State University, Moscow, 119991, Leninskie Gory 1/3, Russia.
L Mínguez-AlarcónEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, 14th Floor, Boston, MA, 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 3rd Floor West, Boston, MA, 02215, USA.
R HauserEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, 14th Floor, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health Kresge Building, 9th Floor, Boston, MA, 02115, USA.
P L WilliamsDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 2, 4th Floor, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health Kresge Building, 9th Floor, Boston, MA, 02115, USA.
Harvard University · USLomonosov Moscow State University · RUBrigham and Women's Hospital · USInstitute for Prevention and Occupational Medicine · DE

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Effects of Environmental Phthalates and Chemical Mixtures on Male Puberty and Semen QualityR01ES014370 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B · 2006 to 2021
$8.2M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES014370
6 · The paper itself

Abstract

backgroundEpidemiological studies have reported associations of anti-androgenic phthalate metabolite concentrations with later onset of male puberty, but few have assessed associations with progression.

objectivesWe examined the association of prepubertal urinary phthalate metabolite concentrations with trajectories of pubertal progression among Russian boys.

methodsAt enrollment (ages 8-9 years), medical history, dietary, and demographic information were collected. At entry and annually to age 19 years, physical examinations including testicular volume (TV) were performed and spot urines collected. Each boy's prepubertal urine samples were pooled, and 15 phthalate metabolites were quantified by isotope dilution LC-MS/MS at Moscow State University. Metabolites of anti-androgenic parent phthalates were included: butylbenzyl (BBzP), di-n-butyl (DnBP), diisobutyl (DiBP), di(2-ethylhexyl) (DEHP) and diisononyl (DiNP) phthalates. We calculated the molar sums of DEHP, DiNP, and all AAP metabolites. We used group-based trajectory models (GBTMs) to identify subgroups of boys who followed similar pubertal trajectories from ages 8-19 years based on annual TV. We used multinomial and ordinal regression models to evaluate whether prepubertal log-transformed phthalate metabolite concentrations were associated with slower or faster pubertal progression trajectories, adjusting for covariates.

results304 boys contributed a total of 752 prepubertal urine samples (median 2, range: 1-6) for creation of individual pools. The median length of follow-up was 10.0 years; 79% of boys were followed beyond age 15. We identified three pubertal progression groups: slower (34%), moderate (43%), and faster (23%) progression. A standard deviation increase in urinary log-monobenzyl phthalate (MBzP) concentrations was associated with higher adjusted odds of being in the slow versus faster pubertal progression trajectory (aOR 1.47, 95% CI 1.06-2.04). None of the other phthalate metabolites were associated with pubertal progression.

conclusionsOn average, boys with higher concentrations of prepubertal urinary MBzP had a slower tempo of pubertal progression, perhaps attributable to the disruption of androgen-dependent biological pathways.

Indexed as

Diethylhexyl PhthalateEnvironmental PollutantsPhthalic AcidsAdolescentAdultAndrogen AntagonistsChromatography, LiquidEnvironmental ExposureHumansMaleTandem Mass SpectrometryYoung AdultAndrogen AntagonistsDiethylhexyl Phthalatediisononyl phthalateEnvironmental Pollutantsphthalic acidPhthalic AcidsBoysEndocrine disrupting chemicalsEnvironmentPhthalatesPubertal progressionPubertyTanner staging

Identifiers

PMID37348639
PMCPMC10575624
OpenAlexW4381336204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.