Evidence map›Paper›PMID 37348627›Full record

ArticleArchives of biochemistry and biophysics2023

Evidence that the catalytic mechanism of heme a synthase involves the formation of a carbocation stabilized by a conserved glutamate.

Elise D Rivett, Hannah G Addis, Jonathan V Dietz, Jayda A Carroll-Deaton, Shipra Gupta, Koji L Foreman, Minh Anh Dang, Jennifer L Fox, Oleh Khalimonchuk, Eric L Hegg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mechanisms of heme transport in the mitochondria.Biochemical Society transactions · 2025
    Review
  5. Comparative Genomics and Characterisation of the Role ofJournal of fungi (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Elise D RivettDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.
Hannah G AddisDepartment of Chemistry and Biochemistry, College of Charleston, Charleston, SC, 29424, USA.
Jonathan V DietzDepartment of Biochemistry, University of Nebraska, Lincoln, NE, 68588, USA.
Jayda A Carroll-DeatonDepartment of Chemistry and Biochemistry, College of Charleston, Charleston, SC, 29424, USA.
Shipra GuptaDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.
Koji L ForemanDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.
Minh Anh DangDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.
Jennifer L FoxDepartment of Chemistry and Biochemistry, College of Charleston, Charleston, SC, 29424, USA. Electronic address: foxjl@cofc.edu.
Oleh KhalimonchukDepartment of Biochemistry, University of Nebraska, Lincoln, NE, 68588, USA; Nebraska Redox Biology Center, University of Nebraska, Lincoln, NE, 68588, USA; Fred & Pamela Buffett Cancer Center, Omaha, NE, 68198, USA. Electronic address: okhalimonchuk2@unl.edu.
Eric L HeggDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA. Electronic address: erichegg@msu.edu.
Michigan State University · USCollege of Charleston · USUniversity of Nebraska–Lincoln · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Mitochondrial Fidelity and HomeostasisR35GM131701 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Oleh Khalimonchuk · 2019 to 2026
$2.4M
Molecular Mechanisms of DiseaseT32GM107001 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F, BLACK, PAUL N. · 2015 to 2019
$1.0M
Biosynthesis and Insertion of Heme A during Cytochrome c Oxidase BiogenesisR01GM101386 · NIGMS · MICHIGAN STATE UNIVERSITY · PI HEGG, ERIC L. · 2012 to 2015
$990k
NIGMS NIH HHS P20 GM103499NIGMS NIH HHS R01 GM101386NIGMS NIH HHS R35 GM131701NIGMS NIH HHS T32 GM107001
6 · The paper itself

Abstract

In eukaryotes and many aerobic prokaryotes, the final step of aerobic respiration is catalyzed by an aa

Indexed as

Glutamic AcidSaccharomyces cerevisiae ProteinsFerrochelataseHemeSaccharomyces cerevisiaeFerrochelataseGlutamic AcidHemeheme aSaccharomyces cerevisiae ProteinsCox15CtaACytochrome c oxidase (Complex IV)Heme a synthaseHeme oOxygen activation

Identifiers

PMID37348627
PMCPMC10529832
OpenAlexW4381384597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.