Evidence map›Paper›PMID 37348497›Full record

ArticleMolecular cell2023

Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.

Meng Wang, Laura T L Brandt, Xiaonan Wang, Holly Russell, Emily Mitchell, Ashley N Kamimae-Lanning, Jill M Brown, Felix A Dingler, Juan I Garaycoechea, Tomoya Isobe and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  5. Fanconi Anemia as a Window into Premalignant Field Cancerization of the Oral Mucosa.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Meng WangDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK. Electronic address: mengwang@cornell.edu.
Laura T L BrandtMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
Xiaonan WangWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Holly RussellMRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Emily MitchellWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; Wellcome Sanger Institute, Hinxton, UK.
Ashley N Kamimae-LanningMRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Jill M BrownMRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Felix A DinglerMRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Juan I GaraycoecheaHubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center, Utrecht, the Netherlands.
Tomoya IsobeWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Sarah J KinstonWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Muxin GuWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
George S VassiliouWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Nicola K WilsonWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Berthold GöttgensWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Ketan J PatelMRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address: ketan.patel@imm.ox.ac.uk.
University of Cambridge · GBWellcome/MRC Cambridge Stem Cell Institute · GBJohn Radcliffe Hospital · GBMRC Laboratory of Molecular Biology · GBMRC Weatherall Institute of Molecular Medicine · GBRoyal Netherlands Academy of Arts and Sciences · NLUniversity of Oxford · GB

Funding

Cancer Research UK 21762Cancer Research UK 23015Cancer Research UK C1163/A21762Cancer Research UK C42693/A23273Cancer Research UK C60150/A23919Medical Research Council MC_PC_17230Medical Research Council MC_U105178811Medical Research Council MC_UU_00016/17Medical Research Council MC_UU_00029/1Medical Research Council MR/S036113/1Wellcome Trust 106202/Z/14/ZWellcome Trust 203151Wellcome Trust 203151/Z/16/ZWellcome Trust 206328/Z/17/Z
6 · The paper itself

Abstract

Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid differentiation bias. However, the drivers and mechanisms that underpin this fundamental switch are not understood. HSCs produce genotoxic formaldehyde that requires protection by the detoxification enzymes ALDH2 and ADH5 and the Fanconi anemia (FA) DNA repair pathway. We find that the HSCs in young Aldh2

Indexed as

AgingAldehydesDNA DamageHematopoiesisTumor Suppressor Protein p53Aldehyde Dehydrogenase, MitochondrialAnimalsFanconi Anemia Complementation Group D2 ProteinHematopoietic Stem CellsHumansLeukemia, Myeloid, AcuteMiceMyeloid CellsSingle-Cell Gene Expression AnalysisTranscriptomeAldehyde Dehydrogenase, MitochondrialAldehydesALDH2 protein, mouseFancd2 protein, mouseFanconi Anemia Complementation Group D2 ProteinTumor Suppressor Protein p53agingaldehydesDNA damageDNA-damage responsehematopoiesismyeloid biasp53

Identifiers

PMID37348497
PMCPMC7614878
OpenAlexW4381548628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.