Evidence map›Paper›PMID 37348131›Full record

ArticleChemical research in toxicology2023

Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity.

Wei Xie, Rongrong Jiang, Jiashu Xie, Robert Vince, Swati S More

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei XieCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-6458-2810
Rongrong JiangCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Jiashu XieCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Robert VinceCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Swati S MoreCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-8733-2029
University of Minnesota · US

Funding

Role of glyoxalase-1 in Alzheimer's disease pathogenesis and therapyR01AG062469 · NIA · UNIVERSITY OF MINNESOTA · PI MORE, SWATI S · 2019 to 2023
$1.9M
NIA NIH HHS R01 AG062469
6 · The paper itself

Abstract

Overdose of acetaminophen, a widely used antipyretic and analgesic drug, is one of the leading causes of drug-induced acute liver injury in the United States and worldwide. Phase-I metabolism of acetaminophen generates the toxic

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryAnimalsAntidotesBenzoquinonesDisease Models, AnimalGuanabenzIminesLiverMiceMice, Inbred C57BLOxidative StressAcetaminophenAntidotesBenzoquinonesGuanabenzIminesN-acetyl-4-benzoquinoneimine

Identifiers

PMID37348131
PMCPMC10355191
OpenAlexW4381715981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.