Evidence map›Paper›PMID 37348026›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Elevated renal afferent nerve activity in a rat model of endothelin B receptor deficiency.

Bryan K Becker, Caroline M Grady, Alexa E Markl, Alfredo A Torres Rodriguez, David M Pollock

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bryan K BeckerCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-2900-0795
Caroline M GradyCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Alexa E MarklCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Alfredo A Torres RodriguezCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
David M PollockCardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-0233-2362
University of Alabama at Birmingham · US

Funding

Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
Prospective Effects of Early Life Stress and Protective Factors on Vascular Function and Inflammation in Young AdulthoodP01HL158500 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jennifer S Pollock · 2023 to 2026
$11.1M
UAB KUH KURER25DK115353 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jennifer S Pollock · 2018 to 2026
$1.0M
Renal Sensory Nerve Contribution to HypertensionK01HL159047 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BECKER, BRYAN K · 2021 to 2025
$808k
NHLBI NIH HHS K01 HL159047NHLBI NIH HHS P01 HL136267NHLBI NIH HHS P01 HL158500NIDDK NIH HHS R25 DK115353
6 · The paper itself

Abstract

Renal nerves have been an attractive target for interventions aimed at lowering blood pressure; however, the specific roles of renal afferent (sensory) versus efferent sympathetic nerves in mediating hypertension are poorly characterized. A number of studies have suggested that a sympathoexcitatory signal conveyed by renal afferents elicits increases in blood pressure, whereas other studies identified sympathoinhibitory afferent pathways. These sympathoinhibitory pathways have been identified as protective against salt-sensitive increases in blood pressure through endothelin B (ET

Indexed as

HypertensionKidneyAfferent PathwaysAnimalsBlood PressureEndothelin-1RatsReceptor, Endothelin AReceptor, Endothelin BSodium Chloride, DietaryEndothelin-1Receptor, Endothelin AReceptor, Endothelin BSodium Chloride, Dietaryautonomicsblood pressuresaltsensory nerves

Identifiers

PMID37348026
PMCPMC10396274
OpenAlexW4381612986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.