Evidence map›Paper›PMID 37347292›Full record

ArticleJournal of neurology2023

Establishing normative data for the evaluation of cognitive performance in Huntington's disease considering the impact of gender, age, language, and education.

Alžbeta Mühlbäck, Josef Mana, Michael Wallner, Wiebke Frank, Katrin S Lindenberg, Rainer Hoffmann, Olga Klempířová, Jiří Klempíř, G Bernhard Landwehrmeyer, Ondrej Bezdicek and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Normative Data for Objective ADHD Smartphone Application in a General Population.Clinical practice and epidemiology in mental health : CP & EMH · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Alžbeta MühlbäckDepartment of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany. alzbeta.muehlbaeck@uni-ulm.de.ORCID http://orcid.org/0000-0002-0385-3071
Josef ManaDepartment of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Michael Wallner2mt Software GmbH, Ulm, Germany.
Wiebke FrankDepartment of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany.
Katrin S LindenbergDepartment of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany.
Rainer HoffmannHuntington Center South, kbo-Isar-Amper-Klinikum, Taufkirchen, Germany.
Olga KlempířováDepartment of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Jiří KlempířDepartment of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
G Bernhard LandwehrmeyerDepartment of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany.
Ondrej BezdicekDepartment of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
REGISTRY investigators of the European Huntington’s Disease Network, the Enroll-HD investigators
Charles University · CZUniversität Ulm · DEIsar-Amper-Klinikum München-Ost · DESoftware (Germany) · DE

Funding

EU Joint Programme - Neurodegenerative Disease Research Project Nr. 8F19004Rare Diseases Clinical Research Network Project ID No 739510Univerzita Karlova v Praze Grant PROGRES Q27/LF1
6 · The paper itself

Abstract

backgroundA declining cognitive performance is a hallmark of Huntington's disease (HD). The neuropsychological battery of the Unified HD Rating Scale (UHDRS'99) is commonly used for assessing cognition. However, there is a need to identify and minimize the impact of confounding factors, such as language, gender, age, and education level on cognitive decline.

objectivesAim is to provide appropriate, normative data to allow clinicians to identify disease-associated cognitive decline in diverse HD populations by compensating for the impact of confounding factors

methodsSample data, N = 3267 (60.5% females; mean age of 46.9 years (SD = 14.61, range 18-86) of healthy controls were used to create a normative dataset. For each neuropsychological test, a Bayesian generalized additive model with age, education, gender, and language as predictors was constructed to appropriately stratify the normative dataset.

resultsWith advancing age, there was a non-linear decline in cognitive performance. In addition, performance was dependent on educational levels and language in all tests. Gender had a more limited impact. Standardized scores have been calculated to ease the interpretation of an individual's test outcome. A web-based online tool has been created to provide free access to normative data.

conclusionFor defined neuropsychological tests, the impact of gender, age, education, and language as factors confounding disease-associated cognitive decline can be minimized at the level of a single patient examination.

Indexed as

Huntington DiseaseBayes TheoremCognitionEducational StatusFemaleHumansLanguageMaleMiddle AgedNeuropsychological TestsCognitionCognitive declineHuntington’s diseaseNeuropsychological testingNormative dataOnline calculator

Identifiers

PMID37347292
PMCPMC10511566
OpenAlexW4381598218

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.