Evidence map›Paper›PMID 37347242›Full record

GuidelineGenetics in medicine : official journal of the American College of Medical Genetics2023

ACMG SF v3.2 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG).

David T Miller, Kristy Lee, Noura S Abul-Husn, Laura M Amendola, Kyle Brothers, Wendy K Chung, Michael H Gollob, Adam S Gordon, Steven M Harrison, Ray E Hershberger and 5 more

Registry-linked trialAbstract readPractice Guideline
In one paragraph

Guideline in Genetics in medicine : official journal of the American College of Medical Genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07652580 (Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma Across the Military Healthcare System), which is not on this map. Cited by 266 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
266citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07652580 recruitingnot on this mapstarted 2025, after this paper: background citation

Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma Across the Military Healthcare System

TypeobservationalSponsorHenry M. Jackson Foundation for the Advancement of Military MedicineRan2025 to 2028Enrolled300ConditionsNon-Hodgkin Lymphoma, Lymphoma Non-Hodgkin, B-cell Lymphoma, Immune Dysregulation
3 · Its place in the literature

Who cites it

266 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Guideline
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  7. Pooled it
  8. Incremental yield of exome sequencing over standard prenatal testing in structurally normal fetuses: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Pooled it
  9. Trial
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  12. Review
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206 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

David T MillerDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA.
Kristy LeeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Noura S Abul-HusnDepartment of Medicine, Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY; 23andMe, Inc., Sunnyvale, CA.
Laura M AmendolaIllumina, Inc., San Diego, CA.
Kyle BrothersDepartment of Pediatrics, University of Louisville, Louisville, KY.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, NY.
Michael H GollobDivision of Cardiology, Department of Physiology, University of Toronto, Toronto, ON, Canada.
Adam S GordonDepartment of Pharmacology, Center for Genetic Medicine, Northwestern University, Chicago, IL.
Steven M HarrisonAmbry Genetics, Aliso Viejo, CA.
Ray E HershbergerDivisions of Human Genetics and Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH.
Teri E KleinDepartments of Biomedical Data Science and Medicine, Stanford University, Stanford, CA.
C Sue RichardsDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR.
Douglas R StewartClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Christa Lese MartinAutism & Developmental Medicine Institute, Geisinger, Danville, PA.
ACMG Secondary Findings Working Group. Electronic address: documents@acmg.netAmerican College of Medical Genetics and Genomics, Bethesda, MD.

Funding

Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8M
Genetic Modifiers of Cancer RiskZIACP010142 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MIRABELLO, LISA · 2009 to 2025
$17.1M
PharmGKB: pharmacogenomics discovery and implementationU24HG010615 · NHGRI · STANFORD UNIVERSITY · PI TERI Ellen KLEIN, Michelle Whirl-Carrillo · 2020 to 2026
$9.5M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010142NHGRI NIH HHS U24 HG010615
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ExomeGenetics, MedicalBase SequenceGenetic TestingGenome, HumanGenomicsHumansIncidental FindingsPolicyUnited StatesExome sequencingGenome sequencingIncidental findingsSecondary findings

Identifiers

PMID37347242
PMCPMC10524344

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.