Evidence map›Paper›PMID 37347171›Full record

ArticleJournal of clinical microbiology2023

Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene,

Barbara A Brown-Elliott, Richard J Wallace, Nancy L Wengenack, Sean D Workman, Andrew D S Cameron, Georgie Bush, M Dolores Hughes, Stephanie Melton, Bibiana Gonzalez-Ramirez, Eliana Rodriguez and 6 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.International journal of molecular sciences · 2026
    Review
  3. CutaneousMicroorganisms · 2026
    Article
  4. Article
  5. Article
  6. Giant linear plasmids in Mycobacterium avium harbour a tRNA array unit.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Macrolide resistance due toMicrobiology spectrum · 2025
    Article
  11. Regulation of erm(T) MLSnpj antimicrobials and resistance · 2024
    Article
  12. Managing Complicated Nontuberculous Mycobacteria Infections in Plastic Surgery.Plastic and reconstructive surgery. Global open · 2024
    Article
  13. Article
  14. Article
  15. Population genetic analysis of clinicalFrontiers in cellular and infection microbiology · 2024
    Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Barbara A Brown-ElliottMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.ORCID 0000-0002-3091-1169
Richard J WallaceMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Nancy L WengenackDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-2853-8219
Sean D WorkmanDepartment of Biology, University of Regina, Regina, Saskatchewan, Canada.ORCID 0000-0001-8807-4466
Andrew D S CameronDepartment of Biology, University of Regina, Regina, Saskatchewan, Canada.ORCID 0000-0003-1560-8572
Georgie BushMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
M Dolores HughesMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Stephanie MeltonMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Bibiana Gonzalez-RamirezMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Eliana RodriguezMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Kavya SomayajiMycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
Courtney KlapperichDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Mary ViersDivision of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Ayooluwa J BolajiCadham Provincial Laboratory, Diagnostic Services, Shared Health, Winnipeg, Manitoba, Canada.
Emma RempelCadham Provincial Laboratory, Diagnostic Services, Shared Health, Winnipeg, Manitoba, Canada.
David C AlexanderCadham Provincial Laboratory, Diagnostic Services, Shared Health, Winnipeg, Manitoba, Canada.
The University of Texas Health Science Center at Tyler · USManitoba Health · CAMayo Clinic · USUniversity of Regina · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrolides are a mainstay of therapy for infections due to nontuberculous mycobacteria (NTM). Among rapidly growing mycobacteria (RGM), inducible macrolide resistance is associated with four chromosomal 23S rRNA methylase (

Indexed as

MycobacteriumMycobacterium chelonaeMycobacterium Infections, NontuberculousAnti-Bacterial AgentsClarithromycinDrug Resistance, BacterialHumansMacrolidesMethyltransferasesMicrobial Sensitivity TestsNontuberculous MycobacteriaPlasmidsAnti-Bacterial AgentsClarithromycinMacrolidesMethyltransferasesrRNA (adenosine-O-2'-)methyltransferaseclarithromycinerm genemacrolide resistancemycobacterial plasmidsMycobacterium chelonaenanopore genomic sequencingrapidly growing mycobacteriawhole-genomic sequencing

Identifiers

PMID37347171
PMCPMC10358161
OpenAlexW4381598890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.