Evidence map›Paper›PMID 37346981›Full record

ArticleMolecular therapy. Nucleic acids2023

Liver lobe-specific hydrodynamic gene delivery to baboons: A preclinical trial for hemophilia gene therapy.

Kenya Kamimura, Tsutomu Kanefuji, Takeshi Suda, Takeshi Yokoo, Guisheng Zhang, Yutaka Aoyagi, Dexi Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kenya KamimuraDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8510, Japan.
Tsutomu KanefujiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8510, Japan.
Takeshi SudaDepartment of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minami Uonuma, Niigata 949-7302, Japan.
Takeshi YokooDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8510, Japan.
Guisheng ZhangDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
Yutaka AoyagiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8510, Japan.
Dexi LiuDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
Niigata University · JPUniversity of Georgia · USNiigata University Medical and Dental Hospital · JP

Funding

New Polymeric Carriers for Pulmonary Gene DeliveryR01HL075542 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIU, DEXI · 2004 to 2007
$1.3M
Bifunctional Compounds for Targeted Gene DeliveryR01EB002946 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIU, DEXI · 2003 to 2006
$1.1M
NHLBI NIH HHS R01 HL075542NIBIB NIH HHS R01 EB002946
6 · The paper itself

Abstract

Hydrodynamics-based gene transfer has been successfully employed for

Indexed as

baboongene therapyhemophiliahuman factor IXhydrodynamic gene deliverylarge animalMT: Delivery Strategiesnon-viral vector

Identifiers

PMID37346981
PMCPMC10280096
OpenAlexW4377043875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.