Evidence map›Paper›PMID 37346950›Full record

ReviewRSC advances2023

Recent trends in macromolecule-conjugated hybrid quantum dots for cancer theranostic applications.

Lokesh Kumar Boopathy, Thiyagarajan Gopal, Anitha Roy, Rakhee Rathnam Kalari Kandy, Madan Kumar Arumugam

Open access · goldAbstract readReview
In one paragraph

Review in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Lokesh Kumar BoopathyMolecular Research Laboratory, Meenakshi Medical College Hospital and Research Institute, MAHER Kanchipuram 631552 Tamil Nadu India.
Thiyagarajan GopalCentre for Laboratory Animal Technology and Research, Sathyabama Institute of Science and Technology Chennai-600119 Tamil Nadu India.ORCID https://orcid.org/0000-0003-1031-6300
Anitha RoyDepartment of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Chennai-600077 Tamil Nadu India.
Rakhee Rathnam Kalari KandyMarlene and Stewart Greenebaum Comprehensive Cancer Center, School of Medicine, University of Maryland Baltimore-21201 MD USA.
Madan Kumar ArumugamCancer Biology Laboratory, Centre for Molecular and Nanomedical Sciences, Sathyabama Institute of Science and Technology Chennai-600119 Tamil Nadu India madankumarbio@gmail.com madankumar@sathyabama.ac.in +91-9942110146.ORCID https://orcid.org/0000-0003-0567-7857
Sathyabama Institute of Science and Technology · INMeenakshi Academy of Higher Education and Research · INSaveetha University · INUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantum dots (QDs) are small nanoparticles with semiconductor properties ranging from 2 to 10 nanometers comprising 10-50 atoms. The single wavelength excitation character of QDs makes it more significant, as it can excite multiple particles in a confined surface simultaneously by narrow emission. QDs are more photostable than traditional organic dyes; however, when injected into tissues, whole animals, or ionic solutions, there is a significant loss of fluorescence. HQD-based probes conjugated with cancer-specific ligands, antibodies, or peptides are used in clinical diagnosis. It is more precise and reliable than standard immunohistochemistry (IHC) at minimal protein expression levels. Advanced clinical studies use photodynamic therapy (PDT) with fluorescence imaging to effectively identify and treat cancer. Recent studies revealed that a combination of unique characteristics of QDs, including their fluorescence capacity and abnormal expression of miRNA in cancer cells, were used for the detection and monitoring progression of cancer. In this review, we have highlighted the unique properties of QDs and the theranostic behavior of various macromolecule-conjugated HQDs leading to cancer treatment.

Identifiers

PMID37346950
PMCPMC10281231
OpenAlexW4381435472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.