ArticleFrontiers in cellular neuroscience2023
Moderate intrinsic phenotypic alterations in
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Article in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed.
- C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression.Stem cell reports · 2026Article
- Microglia in C9orf72-associated amyotrophic lateral sclerosis: More or less active?Neural regeneration research · 2026Article
- High-Dimensional Sensitivity Analysis for Genomic Studies: An Adversarial Framework for Learning Worst-Case Latent Confounders.bioRxiv : the preprint server for biology · 2026Article
- Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells.Stem cell reports · 2026Review
- PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids.Brain : a journal of neurology · 2026Article
- Article
- C9orf72 hexanucleotide repeat expansions impair microglial response in ALS.Nature neuroscience · 2025Article
- ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice.Nature communications · 2025Article
- Review
- Review
- Article
- Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB.Molecular neurodegeneration · 2024Article
- Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.Nature communications · 2024Article
- Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients.Acta neuropathologica · 2024Article
- Glycine-Alanine Dipeptide Repeat Protein from C9-ALS Interacts with Sulfide Quinone Oxidoreductase (SQOR) to Induce the Activity of the NLRP3 Inflammasome in HMC3 Microglia: Irisflorentin Reverses This Interaction.Antioxidants (Basel, Switzerland) · 2023Article
- Review
- C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.Nature communications · 2023Article
- Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders.Frontiers in psychiatry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
Ileana LorenziniDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Eric AlsopNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, United States.
Jennifer LevyDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Lauren M GittingsDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Deepti LallCenter for Neural Science and Medicine, Cedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, CA, United States.
Benjamin E RabichowDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Stephen MooreDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Ryan PeveyDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Lynette M BustosDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Camelia BurciuDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Divya BhatiaDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Mo SingerDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Justin SaulDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Amanda McQuadeDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States.
Makis TziorasUK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Thomas A MotaCenter for Neural Science and Medicine, Cedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, CA, United States.
Amber LogemannNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, United States.
Jamie RoseUK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Sandra AlmeidaDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, United States.
Fen-Biao GaoDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, United States.
Michael MarksDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Christopher J DonnellyDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Elizabeth HutchinsNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, United States.
Shu-Ting HungDepartment of Stem Cell Biology Regenerative Medicine, USC Keck School of Medicine, Los Angeles, CA, United States.
Justin IchidaDepartment of Stem Cell Biology Regenerative Medicine, USC Keck School of Medicine, Los Angeles, CA, United States.
Robert BowserDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Tara Spires-JonesUK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Mathew Blurton-JonesDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States.
Tania F GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
Robert H BalohCenter for Neural Science and Medicine, Cedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, CA, United States.
Kendall Van Keuren-JensenNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, United States.
Rita SattlerDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Funding
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MPredoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0MThe role of an aberrant synaptome in microglia-associated synaptic pruning in C9orf72-FTDR01NS120331 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI SATTLER, RITA, VAN KEUREN-JENSEN, KENDALL R · 2021 to 2025
$4.2MUnderstanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6MTraining Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3MUnderstanding Frontotemporal Dementia Using Drosophila and iPSC ModelsRF1NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2022 to 2022
$2.1MRole of C9orf72 in NeurodegenerationR01NS097545 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI BALOH, ROBERT · 2016 to 2020
$2.0MCharacterization of TASK-1 Modulation of Dipeptide Repeat Protein-Mediated Toxicity in iPSC-derived C9ORF72 Patient Neurons.R21NS119952 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALMEIDA, SANDRA · 2020 to 2020
$461kBLRD VA I01 BX003625NIA NIH HHS P30 AG019610NINDS NIH HHS R01 NS097545NINDS NIH HHS R01 NS101986NINDS NIH HHS R01 NS120331NINDS NIH HHS R21 NS119952NINDS NIH HHS RF1 NS101986NINDS NIH HHS T32 NS007433NINDS NIH HHS T32 NS082174
Abstract
While motor and cortical neurons are affected in
Indexed as
amyotrophic lateral sclerosisC9orf72frontotemporal dementiaiPSC-microglianeuroinflammation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.