ArticleWorld journal of gastroenterology2023
Metronomic capecitabine inhibits liver transplant rejection in rats by triggering recipients' T cell ferroptosis.
Article in World journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Metronomic Capecitabine Triggers Ferroptosis in Hepatocellular Carcinoma Cells Through Inhibition of TYMS.Cancer medicine · 2026Article
- Laparoscopic radical gastrectomy for gastric cancer following liver transplantation: a report of a rare and complex case and a multidisciplinary management strategy.Frontiers in medicine · 2026Article
- Ginkgolic acid inhibits CD8Journal of pharmaceutical analysis · 2025Article
- Immunomodulatory Effects of Polysaccharides fromFoods (Basel, Switzerland) · 2025Article
- Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats.Renal failure · 2024Article
- Effect of sulfasalazine on ferroptosis during intestinal injury in rats after liver transplantation.Scientific reports · 2024Article
- Transplant oncology and anti-cancer immunosuppressants.Frontiers in immunology · 2024Review
- Ferroptosis in the post-transplantation inflammatory response.Cellular immunologyArticle
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCapecitabine (CAP) is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation (LT) in clinical studies. Our previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress in healthy mice. Ferroptosis, a newly defined non-apoptotic cell death that occurs in response to iron overload and lethal levels of lipid peroxidation, is an important mechanism by which CAP induces cell death. Therefore, ferroptosis may also play an important role in CAP-induced T cell death and play an immunosuppressive role in acute rejection after trans-plantation.
aimTo investigate the functions and underlying mechanisms of antirejection effects of metronomic CAP.
methodsA rat LT model of acute rejection was established, and the effect of metronomic CAP on splenic hematopoietic function and acute graft rejection was evaluated 7 d after LT.
resultsWith no significant myelotoxicity, metronomic CAP alleviated graft injury (Banff score 9
conclusionMetronomic CAP can suppress acute allograft rejection in rats by triggering CD3
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