ArticleJournal of biomechanical engineering2023
Comparison of Deformation Patterns Excited in the Human Brain In Vivo by Harmonic and Impulsive Skull Motion.
Article in Journal of biomechanical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 10 citations in OpenAlex.
- Multiecho Fat-Water Spiral MR Elastography With Distributed Encoding for Simultaneously Imaging Brain and Skull Displacement.Magnetic resonance in medicine · 2026Article
- Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026Article
- Noninvasive mapping of shear strain predicts the anatomical distribution of mild traumatic brain injury.NeuroImage. Clinical · 2026Article
- Detection of transient tissue displacement using wavelet MR elastography: Phantom validation and in vivo human brain repeatability study.Magnetic resonance in medicine · 2025Article
- Average Biomechanical Responses of the Human Brain Grouped by Age and Sex.Annals of biomedical engineering · 2025Article
- Effects of anatomy and head motion on spatial patterns of deformation in the human brain.Annals of biomedical engineering · 2025Article
- Full-field, frequency-domain comparison of simulated and measured human brain deformation.Biomechanics and modeling in mechanobiology · 2025Article
- Wavelet MRE: Imaging propagating broadband acoustic waves with wavelet-based motion-encoding gradients.Magnetic resonance in medicine · 2024Article
- Effect of Direction and Frequency of Skull Motion on Mechanical Vulnerability of the Human Brain.Journal of biomechanical engineering · 2023Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Noninvasive measurements of brain deformation in human participants in vivo are needed to develop models of brain biomechanics and understand traumatic brain injury (TBI). Tagged magnetic resonance imaging (tagged MRI) and magnetic resonance elastography (MRE) are two techniques to study human brain deformation; these techniques differ in the type of motion and difficulty of implementation. In this study, oscillatory strain fields in the human brain caused by impulsive head acceleration and measured by tagged MRI were compared quantitatively to strain fields measured by MRE during harmonic head motion at 10 and 50 Hz. Strain fields were compared by registering to a common anatomical template, then computing correlations between the registered strain fields. Correlations were computed between tagged MRI strain fields in six participants and MRE strain fields at 10 Hz and 50 Hz in six different participants. Correlations among strain fields within the same experiment type were compared statistically to correlations from different experiment types. Strain fields from harmonic head motion at 10 Hz imaged by MRE were qualitatively and quantitatively similar to modes excited by impulsive head motion, imaged by tagged MRI. Notably, correlations between strain fields from 10 Hz MRE and tagged MRI did not differ significantly from correlations between strain fields from tagged MRI. These results suggest that low-frequency modes of oscillation dominate the response of the brain during impact. Thus, low-frequency MRE, which is simpler and more widely available than tagged MRI, can be used to illuminate the brain's response to head impact.
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