ArticlemBio2023
Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales.
Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- The gut microbiota and host immunity synergistically orchestrate colonization resistance.Gut microbes · 2026Review
- Article
- Specific and broad-spectrum antibacterial effectors of type VI secretion system drive competition ofMicrobiology spectrum · 2026Article
- Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosis.mSystems · 2026Article
- Genome-Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus.MicrobiologyOpen · 2026Article
- "Molecular insights into the bactericidal toxin Tle1 of Pseudomonas aeruginosa: Interaction with VgrG, its adaptor, and its immunity protein".The Journal of biological chemistry · 2026Article
- An electron transport complex required in the gut sensitizesProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A broad-spectrum anti-fungal effector dictates bacterial-fungal interkingdom interactions.PLoS pathogens · 2025Article
- Article
- Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system.bioRxiv : the preprint server for biology · 2025Article
- An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE.PLoS biology · 2025Article
- A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont.Science (New York, N.Y.) · 2024Article
- The type II secretion system as an underappreciated and understudied mediator of interbacterial antagonism.Infection and immunity · 2024Review
- Bactericidal effectors of themBio · 2024Article
- T6SS nuclease effectors inJournal of bacteriology · 2024Article
- A pyocin-like T6SS effector mediates bacterial competition inMicrobiology spectrum · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bacteroidales use type VI secretion systems (T6SS) to competitively colonize and persist in the colon. We identify a horizontally transferred T6SS with Ntox15 family nuclease effector (Tde1) that mediates interbacterial antagonism among Bacteroidales, including several derived from a single human donor. Expression of cognate (Tdi1) or orphan immunity proteins in acquired interbacterial defense systems protects against Tde1-dependent attack. We find that immunity protein interaction induces a large effector conformational change in Tde nucleases, disrupting the active site and altering the DNA-binding site. Crystallographic snapshots of isolated Tde1, the Tde1/Tdi1 complex, and homologs from
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.