Evidence map›Paper›PMID 37345845›Full record

ArticleAmerican journal of physiology. Renal physiology2023

The role of Gata3 in renin cell identity.

Jesus S Neyra, Silvia Medrano, Alexandre De Goes Martini, Maria Luisa S Sequeira-Lopez, R Ariel Gomez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Krüppel-like factor 2 regulates renin expression in mature juxtaglomerular cells.American journal of physiology. Renal physiology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jesus S NeyraDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States.ORCID 0009-0008-5122-2937
Silvia MedranoDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States.ORCID 0000-0002-8516-0788
Alexandre De Goes MartiniDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States.ORCID 0000-0003-3169-014X
Maria Luisa S Sequeira-LopezDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States.ORCID 0000-0002-4459-7940
R Ariel GomezDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States.ORCID 0000-0002-5124-8255
University of Virginia · US

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Plasticity of renin cells in the kidney vasculatureR01DK116718 · NIDDK · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2018 to 2022
$2.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
Fate of the kidney vasculature during partial neonatal ureteral obstructionR01DK116196 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL148044NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK116196NIDDK NIH HHS R01 DK116718
6 · The paper itself

Abstract

Renin cells are precursors for other cell types in the kidney and show high plasticity in postnatal life in response to challenges to homeostasis. Our previous single-cell RNA-sequencing studies revealed that the dual zinc-finger transcription factor

Indexed as

Kidney DiseasesReninAnimalsGATA3 Transcription FactorKidneyKidney GlomerulusMiceZincGata3 protein, mouseGATA3 Transcription FactorReninZinccell fatecell plasticityrenal arteriolesrenin-angiotensin system

Identifiers

PMID37345845
PMCPMC10396225
OpenAlexW4381598724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.