Evidence map›Paper›PMID 37345832›Full record

ArticleJournal of the American Heart Association2023

Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site I

Austin D Read, Rachel E T Bentley, Ashley Y Martin, Jeffrey D Mewburn, Elahe Alizadeh, Danchen Wu, Patricia D A Lima, Kimberly J Dunham-Snary, Bernard Thébaud, Willard Sharp and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. The role of mitochondria in iron overload-induced damage.Journal of translational medicine · 2024
    Review
  6. Ductus Arteriosus in Fetal and Perinatal Life.Journal of cardiovascular development and disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Austin D ReadDepartment of Medicine Queen's University Kingston Ontario Canada.ORCID 0000-0001-8394-6982
Rachel E T BentleyDepartment of Medicine Queen's University Kingston Ontario Canada.ORCID 0000-0003-0486-8467
Ashley Y MartinDepartment of Medicine Queen's University Kingston Ontario Canada.ORCID 0009-0005-8170-1638
Jeffrey D MewburnDepartment of Medicine Queen's University Kingston Ontario Canada.ORCID 0000-0002-1365-4228
Elahe AlizadehQueen's CardioPulmonary Unit Queen's University Kingston Ontario Canada.ORCID 0000-0003-4046-1226
Danchen WuDepartment of Medicine Queen's University Kingston Ontario Canada.ORCID 0000-0003-3901-5907
Patricia D A LimaQueen's CardioPulmonary Unit Queen's University Kingston Ontario Canada.ORCID 0000-0002-6456-2470
Kimberly J Dunham-SnaryDepartment of Medicine Queen's University Kingston Ontario Canada.ORCID 0000-0001-9760-342X
Bernard ThébaudDepartment of Cellular and Molecular Medicine University of Ottawa Ottawa Ontario Canada.ORCID 0000-0003-1844-7145
Willard SharpDepartment of Medicine The University of Chicago Chicago IL USA.ORCID 0000-0002-7175-3523
Stephen L ArcherDepartment of Medicine Queen's University Kingston Ontario Canada.ORCID 0000-0003-1106-3202
Queen's University · CAUniversity of Chicago · USUniversity of Ottawa · CA

Funding

O2 sensing in the human and rabbit ductus arteriosus.R01HL071115 · NHLBI · UNIVERSITY OF CHICAGO · PI ARCHER, STEPHEN L · 2004 to 2015
$3.1M
Pharmacological Induced Torpor/Hypothermia As A Novel Therapy for Improving Post Cardiac Arrest Resuscitation OutcomesR01HL133675 · NHLBI · UNIVERSITY OF CHICAGO · PI SHARP, WILLARD WILLIAM · 2016 to 2020
$2.0M
Impaired mitochondrial fusion in pulmonary arterial hypertensionRC1HL099462 · NHLBI · UNIVERSITY OF CHICAGO · PI ARCHER, STEPHEN L · 2009 to 2010
$1.0M
NHLBI NIH HHS R01 HL071115NHLBI NIH HHS R01 HL133675NHLBI NIH HHS RC1 HL099462
6 · The paper itself

Abstract

Background As partial pressure of oxygen (pO

Indexed as

Ductus ArteriosusAnimalsCalciumElectronsElectron TransportHumansOxygenRabbitsReactive Oxygen SpeciesRotenoneX-Ray MicrotomographyCalciumOxygenReactive Oxygen SpeciesRotenonemitochondrial O2 sensorpatent ductus arteriosusredox signalingsuppressor of site IIIQ0 electron leak (S3QEL)suppressor of site IQ electron leak (S1QEL)

Identifiers

PMID37345832
PMCPMC10356098
OpenAlexW4381598963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.