SynthesisJournal of the American Heart Association2023
The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review.
Synthesis in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 5 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Embedding structural and social determinants of cardiovascular health into medical education: a systematic review of pedagogical frameworks.Frontiers in medicine · 2026Pooled it
- Impact of neighbourhood and environmental factors on the risk of incident cardiovascular disease: a systematic review and meta-analysis.European journal of preventive cardiology · 2025Pooled it
- Part 3: Ethics: 2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.Circulation · 2025Guideline
- Social Disadvantage and Disparities in Chronic Liver Disease: A Systematic Review.The American journal of gastroenterology · 2024Pooled it
- A Systematic Review of Artificial Intelligence Models for Time-to-Event Outcome Applied in Cardiovascular Disease Risk Prediction.Journal of medical systems · 2024Pooled it
- Food Insecurity and Its Cardiovascular Implications in Underresourced Communities.Journal of the American Heart Association · 2025Trial
- Background and design of the empowering cardiovascular health in grandfamilies (ECHG) study: A mixed methods study research protocol.International journal of nursing studies advances · 2026Article
- Observational
- The social context and environment as targets for heart failure prevention.Heart failure reviews · 2026Review
- Adaptation of a fair individualized polysocial risk score for hospitalization risk prediction.JAMIA open · 2026Article
- Associations of food security and food assistance with cardiovascular morbidity and mortality among postmenopausal women from the women's health initiative.Journal of epidemiology and community health · 2026Article
- Clustering of Social Determinants of Health and Their Association With Adverse Cardiovascular Outcomes in Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Pregnancy as a Window for Hypertension and Cardiovascular Prevention in Women: A Life-Course Perspective Based on the 2025 ESC Guidelines.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Review
- Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population.Neurology · 2026Article
- Pathways to Real World Evidence From the Real World of School-Based Physical Fitness Testing (SB-PFT).Learning health systems · 2026Article
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- Subtypes of newly diagnosed type 2 diabetes and risk of complications: analysis of electronic health records in the USA.Diabetologia · 2026Article
- Higher Neighborhood Social Vulnerability is Associated with Lower Life's Essential 8 Cardiovascular Health Scores: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.medRxiv : the preprint server for health sciences · 2026Article
- Leveraging Neighborhood-Level Interventions to Improve Cardiovascular Health: A Scoping Review.Circulation. Population health and outcomes · 2026Article
- Cardiovascular Mortality Risk After Cancer Diagnosis by County-Level Characteristics in the United States 2000-2021.Cancer medicine · 2026Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Addressing social determinants of health (SDoH) may be the next forefront of reducing the enormous burden of CVD. SDoH can be defined as any social, economic, or environmental factor that influences a health outcome. Comprehensive evidence of the role of SDoH in CVD is lacking, nevertheless. This umbrella review aims to give a comprehensive overview of the role of SDoH in CVD. We searched systematic reviews (with or without meta-analyses) using 8 databases and included review reference lists. Four themes (economic circumstances, social/community context, early childhood development, and neighbourhood/built environment) and health literacy in the health/health care theme were considered. Seventy reviews were eligible. Despite the quality of the included reviews being low or critically low, there was consistent evidence that factors relating to economic circumstances and early childhood development themes were associated with an increased risk of CVD and CVD mortality. We also found evidence that factors in the social/community context and neighbourhood/built environment themes, such as social isolation, fewer social roles, loneliness, discrimination, ethnicity, neighborhood socioeconomic status, violence, and environmental attributes, had a role in CVD. SDoH factors without (or with minimal) evidence synthesis for CVD were also identified. In sum, this umbrella review offers evidence that SDoH, especially economic circumstance and early childhood development, play a significant role in CVD. This calls for the strengthening of nonmedical interventions that address multiple factors simultaneously and the inclusion of SDoH in future CVD risk prediction models. Registration URL: https://www.crd.york.ac.uk/prospero/; Unique identifier: CRD42022346994.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.