Evidence map›Paper›PMID 37345813›Full record

ArticleJournal of the American Heart Association2023

Acute Reduction in Left Ventricular Function Following Transcatheter Mitral Edge-to-Edge Repair.

Leor Perl, Mark Kheifets, Ascione Guido, Eustachio Agricola, Paolo Denti, Mirjam Gauri Wild, Fabien Praz, Antonio Popolo Rubbio, Francesco Bedogni, Federico De Marco and 28 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
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  9. Article
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  11. Article
  12. Article
  13. Predictors and clinical impact of worsening left ventricular ejection fraction after mitral transcatheter edge-to-edge repair.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
  14. Review
  15. Review
  16. Evolving indications for transcatheter mitral edge-to-edge repair.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 18 institutions in 8 countries.

Leor PerlDivision of Cardiology, Rabin Medical Center-Beilinson Hospital, Petah-Tikva, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.ORCID 0000-0002-0625-7937
Mark KheifetsDivision of Cardiology, Rabin Medical Center-Beilinson Hospital, Petah-Tikva, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.ORCID 0000-0002-7735-4419
Ascione GuidoIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital Vita-Salute San Raffaele University Milan Italy.ORCID 0000-0002-7727-0573
Eustachio AgricolaIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital Vita-Salute San Raffaele University Milan Italy.ORCID 0000-0002-4834-2187
Paolo DentiIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital Vita-Salute San Raffaele University Milan Italy.ORCID 0000-0002-3075-0203
Mirjam Gauri WildUniversity Heart Center Freiburg/Bad Krozingen Bad Krozingen Germany.ORCID 0000-0003-3626-3876
Fabien PrazDepartment of Cardiology, Bern University Hospital University of Bern Bern, Switzerland.ORCID 0000-0001-5416-165X
Antonio Popolo RubbioClinical and Interventional Cardiology IRCCS Policlinico San Donato San Donato Milanese Italy.ORCID 0000-0002-2451-4626
Francesco BedogniClinical and Interventional Cardiology IRCCS Policlinico San Donato San Donato Milanese Italy.
Federico De MarcoClinical and Interventional Cardiology IRCCS Policlinico San Donato San Donato Milanese Italy.ORCID 0000-0003-3554-6938
Ronen BeeriHeart Institute, Hadassah-Hebrew University Medical Center, Faculty of Medicine Hebrew University Jerusalem Israel.ORCID 0000-0002-8014-0702
Mony ShuvyHeart Institute, Hadassah-Hebrew University Medical Center, Faculty of Medicine Hebrew University Jerusalem Israel.
Francesco MelilloIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital Vita-Salute San Raffaele University Milan Italy.ORCID 0000-0003-2159-1359
Matteo MontorfanoIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital Vita-Salute San Raffaele University Milan Italy.
Xavier FreixaHospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona Barcelona Spain.
Juan Carlos de la Fuente ManceraHospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona Barcelona Spain.ORCID 0000-0001-9770-4626
Arturo GiordanoInvasive Cardiology Unit Pineta Grande Hospital Caserta Italy.
Filippo FinizioInvasive Cardiology Unit Pineta Grande Hospital Caserta Italy.ORCID 0009-0003-5833-4791
Nicolas M Van MieghemDepartment of Interventional Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands.ORCID 0000-0002-2732-1205
J F W OomsDepartment of Interventional Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands.ORCID 0000-0001-7881-7609
Neil FamIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital Vita-Salute San Raffaele University Milan Italy.
Cormac O'ConnorStructural Heart Program, St. Michael's Hospital University of Toronto Toronto, Ontario Canada.ORCID 0000-0002-9854-9063
Stefan ToggweilerHeart Center Lucerne, Department of Cardiology Luzerner Kantonsspital Lucerne Switzerland.ORCID 0000-0002-7860-0298
Amos LeviDivision of Cardiology, Rabin Medical Center-Beilinson Hospital, Petah-Tikva, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.
Yaron ShapiraDivision of Cardiology, Rabin Medical Center-Beilinson Hospital, Petah-Tikva, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.
Shmuel SchwartzenbergDivision of Cardiology, Rabin Medical Center-Beilinson Hospital, Petah-Tikva, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.ORCID 0000-0003-4164-4972
Stefano PidelloDivision of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital University of Turin Turin, Italy.ORCID 0000-0002-2105-7693
Fabrizio D'AscenzoDivision of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital University of Turin Turin, Italy.ORCID 0000-0002-6646-9317
Filippo AngeliniDivision of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital University of Turin Turin, Italy.ORCID 0000-0003-4711-0891
Dan HabermanKaplan Heart Center, Kaplan Medical Center Hebrew University of Jerusalem Rehovot Israel.ORCID 0000-0003-2897-8919
Gabriele CrimiInterventional Cardiology Unit, Cardio Thoraco Vascular Department, IRCCS, Azienda Ospedaliera Universitaria, San Martino l'Istituto Scientifico Tumori University of Genoa Genoa Italy.ORCID 0000-0002-2852-061X
Italo PortoInterventional Cardiology Unit, Cardio Thoraco Vascular Department, IRCCS, Azienda Ospedaliera Universitaria, San Martino l'Istituto Scientifico Tumori University of Genoa Genoa Italy.ORCID 0000-0002-9854-5046
Ottavia CozziInterventional Cardiology Unit IRCCS Humanitas Research Hospital Rozzano-Milan Italy.ORCID 0000-0002-0700-1781
Francesco GianniniInterventional Cardiology Unit Gruppo Villa Maria Care and Research Maria Cecilia Hospital Cotignola Italy.ORCID 0000-0002-0517-1410
Giuseppe TarantiniDepartment of Cardiac, Vascular, Thoracic Sciences and Public Health University of Padua Padua Italy.ORCID 0000-0002-5055-2917
Francesco MaisanoIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital Vita-Salute San Raffaele University Milan Italy.ORCID 0000-0002-3691-1709
Ran KornowskiDivision of Cardiology, Rabin Medical Center-Beilinson Hospital, Petah-Tikva, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.ORCID 0000-0002-7708-8253
MITRA‐EF study *
Vita-Salute San Raffaele University · ITTel Aviv University · ILUniversity of Turin · ITErasmus MC · NLUniversity of Bern · CHIRCCS Policlinico San Donato · ITMartin University · USSt. Michael's Hospital · CAVilla Pineta Hospital · ITCentro Cardiologico Monzino · ITLuzerner Kantonsspital · CHShaare Zedek Medical Center · ILUniversitat de Barcelona · ESUniversity of Padua · ITHebrew University of Jerusalem · ILMaria Cecilia Hospital · ITIRCCS Humanitas Research Hospital · ITKaplan Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Little is known about the impact of transcatheter mitral valve edge-to-edge repair on changes in left ventricular ejection fraction (LVEF) and the effect of an acute reduction in LVEF on prognosis. We aimed to assess changes in LVEF after transcatheter mitral valve edge-to-edge repair for both primary and secondary mitral regurgitation (PMR and SMR, respectively), identify rates and predictors of LVEF reduction, and estimate its impact on prognosis. Methods and Results In this international multicenter registry, patients with both PMR and SMR undergoing transcatheter mitral valve edge-to-edge repair were included. We assessed rates of acute LVEF reduction (LVEFR), defined as an acute relative decrease of >15% in LVEF, its impact on all-cause mortality, major adverse cardiac event (composite end point of all-cause death, mitral valve surgery, and residual mitral regurgitation grade ≥2), and LVEF at 12 months, as well as predictors for LVEFR. Of 2534 patients included (727 with PMR, and 1807 with SMR), 469 (18.5%) developed LVEFR. Patients with PMR were older (79.0±9.2 versus 71.8±8.9 years;

Indexed as

Heart Valve Prosthesis ImplantationMitral Valve InsufficiencyHumansMitral ValveStroke VolumeTreatment OutcomeVentricular Function, Leftafterload mismatchleft ventricular ejection fractionmitral regurgitation

Identifiers

PMID37345813
PMCPMC10356102
OpenAlexW4381597776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.