Evidence map›Paper›PMID 37345792›Full record

ArticleAutophagy2023

The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism.

Elizabeth Delorme-Axford, Xin Wen, Daniel J Klionsky

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. NADCells · 2025
    Review
  6. Article
  7. Med3-mediated NADPH generation to helpApplied and environmental microbiology · 2024
    Article
  8. Article
  9. Multiomics ofInternational journal of molecular sciences · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Elizabeth Delorme-AxfordDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.ORCID 0000-0002-7455-7616
Xin WenLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USOakland University · US

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

Macroautophagy/autophagy is a highly conserved pathway of cellular degradation and recycling that maintains cell health during homeostatic conditions and facilitates survival during stress. Aberrant cellular autophagy contributes to the pathogenesis of human diseases such as cancer, neurodegeneration, and cardiovascular, metabolic and lysosomal storage disorders. Despite decades of research, there remain unanswered questions as to how autophagy modulates cellular metabolism, and, conversely, how cellular metabolism affects autophagy activity. Here, we have identified the yeast metabolic transcription factor Stb5 as a negative regulator of autophagy. Chromosomal deletion of

Indexed as

Saccharomyces cerevisiaeTranscription FactorsAutophagyGene Expression Regulation, FungalHumansNADPSaccharomyces cerevisiae ProteinsNADPSaccharomyces cerevisiae ProteinsStb5 protein, S cerevisiaeTranscription FactorsAld6autophagosomeNADPHpentose phosphate pathwayYmr315wZwf1

Identifiers

PMID37345792
PMCPMC10472870
OpenAlexW4381598998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.