ArticleRenal failure2023
Incidence of bone fractures among patients on maintenance hemodialysis.
Article in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Bone turnover markers associated with cognitive dysfunction in patients undergoing hemodialysis: a cross-sectional study.JBMR plus · 2026Article
- Assessing P1NP/β-CTX as Potential Risk Factors Associated With Different Subtypes of Fragile Hip Fracture in Elderly Patients.Orthopaedic surgery · 2026Article
- The evolution of nephrology practice in Egypt: legacy, current challenges, and future directions-a narrative review.Renal failure · 2025Review
- Advances in noninvasive diagnosis of renal osteodystrophy.Renal failure · 2025Review
- The impact of bone histomorphometry, bone-related biomarkers, and FRAX® on fractures patients with predialysis CKD.Jornal brasileiro de nefrologiaArticle
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with chronic kidney disease, especially those undergoing hemodialysis (HD), have a higher risk of fragility fractures. However, the magnitude of the problem and risk factors associated with fracture incidence have not been well studied in the Kingdom of Saudi Arabia.
methodsThis multicenter retrospective study involved HD centers in Jeddah from 2015 to 2021. This study included all adult HD patients. Patient demographics, medication usage, and clinical and biochemical parameters were collected from the registry records.
resultsThe study included 328 patients on HD, with a mean age of 53 years. The median duration of HD was 47 months. Osteoporosis was found in 9% of the patients, and 8% had a previous parathyroidectomy. Over the observation period, fractures occurred in 32 patients, with an incidence rate of 20 case/1000 end stage kidney disease patients-year. Patients with fractures had a higher rate of osteoporosis, underwent more parathyroidectomy, had longer HD vintage, and higher bone-specific alkaline phosphatase (BSAP) levels. BSAP was the most significant predictor of fracture incidence in the regression analysis. Using a BSAP cutoff value of 96.6 µg/L, the sensitivity and specificity to predict fractures were 81.8% and 49%, respectively.
conclusionThe main risk factors for incident fractures were osteoporosis, previous parathyroidectomy, longer HD vintage, and higher BSAP level. A higher BSAP score was the most significant predictor of incident fractures. This may highlight the importance of monitoring bone turnover markers and the negative impact of high bone turnover on patient health.
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