ArticleRedox report : communications in free radical research2023
Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats.
Article in Redox report : communications in free radical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Lead exposure is associated with increased lead bioaccumulation and a decline in semen quality: a systematic review and meta-analysis.JBRA assisted reproduction · 2025Pooled it
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Compound Xuanju capsules combined with phosphodiesterase-5 inhibitors as a new strategy for erectile dysfunction: a meta-analysis and trial sequential analysis.Frontiers in pharmacology · 2025Pooled it
- Trace Element Dyshomeostasis as a Mediator of Toxic Metal-Induced Reproductive Dysfunction: Mechanistic Insights and Future Perspectives.Biological trace element research · 2026Review
- Effects of MDMA treatment and cessation on sexual behaviour and testicular functions in male sprague-dawley rats.BMC pharmacology & toxicology · 2026Article
- Protective Role of Chrysin against Mercury Chloride-Induced Testicular Damage via Oxidative Stress, Inflammation, Apoptosis, Endoplasmic Reticulum Stress, and Autophagy Pathways.Biological trace element research · 2026Article
- Combined Zinc and Metformin Attenuated Impairment of Corpus Cavernosum Function, Imbalance of Zinc Homeostasis, Apoptosis, and Fibrosis in STZ-Induced Diabetic Mice by Inhibiting the TGF-β1/Smad3 Pathway.Biological trace element research · 2026Article
- Quercetin alleviates radiation-induced erectile dysfunction by modulating oxidative stress and apoptosis through the Nrf2/HO-1 pathway.European journal of medical research · 2026Article
- L-arginine attenuates cisplatin-induced sexual dysfunction in male Wistar rats by modulating circulating testosterone and NO/cGMP signaling.JBRA assisted reproduction · 2026Article
- The aging male: impact of aging on male reproduction.Biogerontology · 2025Review
- Neurotoxic effects of acyclovir: impacts on oxidative stress, inflammation, and neurotransmitter dynamics in male Wistar rats.Metabolic brain disease · 2025Article
- Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats.Biochemistry and biophysics reports · 2025Article
- Ferroptotic- and non-ferroptotic mechanisms associated with doxorubicin-induced male reproductive dysfunction.Toxicology reports · 2025Review
- Mendelian Randomization Reveals Serum Copper as a Micronutrient is a Risk Factor for Erectile Dysfunction.Biological trace element research · 2025Article
- Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.Nutrients · 2025Article
- Perinatal exposure to lead alters male reproductive behaviour and immunoreactivity of androgen and oestrogen receptors in the brain.International journal of experimental pathology · 2025Article
- Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Exploring the role of febuxostat's drug target XOR in erectile dysfunction: insights from human genetics and rat models.Frontiers in medicine · 2025Article
- Association between composite dietary antioxidant index and erectile dysfunction: a cross-sectional study from NHANES.BMC public health · 2024Article
- Cardiometabolic Disorder and Erectile Dysfunction.Cell biochemistry and biophysics · 2024Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe present study evaluated the effect of lead exposure with and without zinc therapy on male sexual and erectile function.
methodsTwenty male Wistar rats were randomly assigned into four groups; the control, zinc-treated, lead-exposed, lead + zinc-treated groups. Administrations were per os daily for 28 days.
resultsZinc co-administration significantly improved absolute and relative penile weights and the latencies and frequencies of mount, intromission, and ejaculation in lead-exposed rats. Also, zinc ameliorated lead-induced reductions in motivation to mate and penile reflex/erection. These findings were accompanied by attenuation of lead-induced suppression of circulating nitric oxide (NO), penile cyclic guanosine monophosphate (cGMP), dopamine, serum luteinizing hormone, follicle-stimulating hormone, and testosterone. In addition, zinc alleviated lead-induced upregulation of penile activities of acetylcholinesterase and xanthine oxidase (XO), and uric acid (UA) and malondialdehyde (MDA) levels. Furthermore, zinc ameliorated the lead-induced decline in penile nuclear factor erythroid 2-related factor 2 (Nrf2) and reduced glutathione (GSH) levels, and catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) activities.
conclusionThis study revealed that co-administration of zinc improves lead-induced sexual and erectile dysfunction by suppressing XO/UA-driven oxidative stress and upregulating testosterone via Nrf2-mediated signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.