Evidence map›Paper›PMID 37345545›Full record

ArticleCirculation. Heart failure2023

Outcomes With Peripheral Venoarterial Extracorporeal Membrane Oxygenation for Suspected Acute Myocarditis: 10-Year Experience From the Extracorporeal Life Support Organization Registry.

Jose I Nunez, E Wilson Grandin, Tiago Reyes-Castro, Marwa Sabe, Pablo Quintero, Shweta Motiwala, Lisa M Fleming, Roy Sriwattanakomen, Jennifer E Ho, Kevin Kennedy and 2 more

Abstract readComment
PubMed Publisher
In one paragraph

Article in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Myocarditis: a primer for intensivists.Intensive care medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jose I NunezDepartment of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (J.I.N.).ORCID 0000-0003-4293-0129
E Wilson GrandinDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).ORCID 0000-0002-4287-334X
Tiago Reyes-CastroDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).ORCID 0000-0001-7329-3375
Marwa SabeDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).
Pablo QuinteroDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).ORCID 0000-0001-9423-5676
Shweta MotiwalaDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).
Lisa M FlemingDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).
Roy SriwattanakomenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).
Jennifer E HoDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).ORCID 0000-0002-7987-4768
Kevin KennedySmith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., K.K.).
Joseph E TonnaExtracorporeal Life Support Organization, Ann Arbor, MI (J.E.T.).ORCID 0000-0001-8879-2628
A Reshad GaranDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.W.G., T.R.-C., M.S., P.Q., S.M., L.M.F., R.S., J.E.H., A.R.G.).ORCID 0000-0001-7510-075X
Beth Israel Deaconess Medical Center · USAlbert Einstein College of Medicine · USDeaconess Hospital · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute myocarditis can result in severe hemodynamic compromise requiring venoarterial extracorporeal membrane oxygenation (VA-ECMO). Outcomes and factors associated with mortality among myocarditis patients are not well described in the modern ECMO era.

methodsWe queried the Extracorporeal Life Support Organization registry from 2011 to 2020 for adults with suspected acute myocarditis undergoing peripheral VA-ECMO support. The primary outcome was in-hospital mortality and was compared to all-comers receiving VA-ECMO in the registry over the same period. Secondary outcomes were rates of bridging to advanced therapies and ECMO complications. We used multivariable logistic regression to examine factors associated with in-hospital mortality.

resultsAmong 850 patients with suspected acute myocarditis receiving peripheral VA-ECMO, the mean age was 41 years, 52% were men, 39% Asian race, and 14.8% underwent extracorporeal cardiopulmonary resuscitation. During the study period, in-hospital mortality steadily declined and was 58.3% for all all-comers receiving VA-ECMO compared with 34.9% for patients with myocarditis (

conclusionsCompared with all-comers supported with VA-ECMO, in-hospital mortality for patients with acute myocarditis is significantly lower, with nearly two-thirds of patients surviving to discharge. Major modifiable risk factors for mortality were ongoing cardiopulmonary resuscitation requiring ECMO and markers of illness severity prior to ECMO.

Indexed as

Extracorporeal Membrane OxygenationHeart FailureMyocarditisAdultFemaleHumansMaleRegistriesRetrospective StudiesRisk FactorsShock, Cardiogeniccardiopulmonary resuscitationextracorporeal membrane oxygenationmyocarditisrisk factor

Identifiers

PMID37345545
OpenAlexW4381598069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.