Evidence map›Paper›PMID 37345464›Full record

ArticleHaematologica2023

Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway.

Cuiping Zhang, Xiaojing Cui, Yi Liu, Fang Wang, Robert Signer, Kapana Nattamai, Daohong Zhou, Yi Zheng, Hartmut Geiger, Fengyi Wan and 1 more

Open access · goldAbstract readLetter
In one paragraph

Article in Haematologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Genetic associations of LXN polymorphisms with toxicities of platinum-based concurrent chemoradiotherapy of nasopharyngeal carcinoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Cuiping ZhangDepartment of Toxicology and Cancer Biology.
Xiaojing CuiDepartment of Toxicology and Cancer Biology.
Yi LiuDepartment of Physiology, University of Kentucky, Lexington, KY.
Fang WangDepartment of Toxicology and Cancer Biology.
Robert SignerDivision of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA.
Kapana NattamaiExperimental Hematology and Cancer Biology, Cincinnati Children Hospital Medical Center, University of Cincinnati, OH.
Daohong ZhouDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX.
Yi ZhengExperimental Hematology and Cancer Biology, Cincinnati Children Hospital Medical Center, University of Cincinnati, OH.
Hartmut GeigerInstitute of Molecular Medicine, Ulm University, Meyerhofstrasse, Ulm.
Fengyi WanDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Ying LiangDepartment of Toxicology and Cancer Biology. ying.liang@uky.edu.
Cincinnati Children's Hospital Medical Center · USCancer Research UK · GBInstitute of Molecular Medicine · INJohns Hopkins University · USThe University of Texas Health Science Center at San Antonio · USUniversity of California San Diego · USUniversity of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
Latexin function in the maintenance and regeneration of the hematopoietic systemR01HL124015 · NHLBI · UNIVERSITY OF KENTUCKY · PI LIANG, YING · 2016 to 2024
$3.6M
Ionizing radiation induced hematological malignanciesR01CA211963 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI ZHOU, DAOHONG · 2017 to 2021
$1.8M
Targeting Latexin for radiation mitigation.R43AI145726 · NIAID · P2D, INC. · PI GABBITA, SOMASUNDAR PRASAD, LIANG, YING · 2019 to 2020
$581k
Latexin in human hematopoietic stem cell expansionR21HL140213 · NHLBI · UNIVERSITY OF KENTUCKY · PI LIANG, YING · 2017 to 2018
$230k
NCI NIH HHS P30 CA177558NCI NIH HHS R01 CA211963NHLBI NIH HHS R01 HL124015NHLBI NIH HHS R21 HL140213NIAID NIH HHS R43 AI145726
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ApoptosisHumans

Identifiers

PMID37345464
PMCPMC10690908
OpenAlexW4381597893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.