Evidence map›Paper›PMID 37345411›Full record

ArticleProceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine2023

Development and experimental validation of a dynamic numerical model for human articular cartilage.

Ben Mellors, Piers Allen, Carolina E Lavecchia, Sophie Mountcastle, Megan E Cooke, Bernard M Lawless, Sophie C Cox, Simon Jones, Daniel M Espino

Abstract read
In one paragraph

Article in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ben MellorsPhysical Sciences for Health CDT, Department of Chemistry, University of Birmingham, Birmingham, UK.
Piers AllenPhysical Sciences for Health CDT, Department of Chemistry, University of Birmingham, Birmingham, UK.
Carolina E LavecchiaDepartment of Mechanical Engineering, University of Birmingham, Birmingham, UK.
Sophie MountcastlePhysical Sciences for Health CDT, Department of Chemistry, University of Birmingham, Birmingham, UK.
Megan E CookeInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Bernard M LawlessDepartment of Mechanical Engineering, University of Birmingham, Birmingham, UK.
Sophie C CoxSchool of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0003-4746-0322
Simon JonesInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Daniel M EspinoDepartment of Mechanical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0001-7608-5619

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to create a preliminary set of experimentally validated Finite Element Analysis (FEA) models, in order to predict the dynamic mechanical behaviour of human articular cartilage (AC). Current models consider static loading with limited independent experimental validation, while the models for this study assess dynamic loading of AC, with direct comparison and validation to physical testing. Three different FEA models of AC were constructed, which considered both linear elastic and hyperelastic models; Neo-Hookean and Ogden. Models were validated using the data collected from compression testing of human femoral heads across 0-1.7 MPa (quasi-static tests and dynamic mechanical analysis). The linear elastic model was inadequate, with a 10-fold over prediction of the displacement dynamic amplitude. The Neo-Hookean model accurately predicted the dynamic amplitude but failed to predict the initial compression of the cartilage, with a 10 times overprediction. The Ogden model provided the best results, with both the initial compression lying within one standard deviation of that observed in the validation data set, and the dynamic amplitude of the same order of magnitude. In conclusion, this study has found that the fast dynamic response of human AC is best represented by a third order Ogden model.

Indexed as

Cartilage, ArticularBiomechanical PhenomenaElasticityFinite Element AnalysisHumansModels, BiologicalPressureStress, MechanicalArticular cartilagedynamic mechanical analysisfinite element analysishyperelastictransient

Identifiers

PMID37345411
PMCPMC10350737

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.