Evidence map›Paper›PMID 37345239›Full record

ArticleCurrent pharmaceutical biotechnology2024

Inhibition of Xanthine Oxidase by 4-nitrocinnamic Acid:

Jianmin Chen, Sijin Yu, Zemin He, Danhong Zhu, Xiaozhen Cai, Zhipeng Ruan, Nan Jin

Abstract read
PubMed Publisher
In one paragraph

Article in Current pharmaceutical biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jianmin ChenSchool of Pharmacy and Medical Technology, Putian University, Fujian, China.ORCID 0000-0003-2934-1493
Sijin YuSchool of Pharmacy and Medical Technology, Putian University, Fujian, China.ORCID 0000-0002-6367-4665
Zemin HeSchool of Pharmacy and Medical Technology, Putian University, Fujian, China.ORCID 0000-0002-3881-8874
Danhong ZhuSchool of Pharmacy and Medical Technology, Putian University, Fujian, China.ORCID 0000-0001-8550-554X
Xiaozhen CaiSchool of Pharmacy and Medical Technology, Putian University, Fujian, China.ORCID 0000-0002-6950-0922
Zhipeng RuanSchool of Pharmacy and Medical Technology, Putian University, Fujian, China.ORCID 0000-0003-4938-2436
Nan JinSchool of Pharmacy and Medical Technology, Putian University, Fujian, China.ORCID 0000-0002-3263-1144
Putian University · CN

Funding

National Natural Science Foundation of China 82001926Putian Science and Technology Bureau 2021ZP01Training Program of Innovation and Entrepreneurship for Undergraduates S202211498003, S202211498004, S202111498016, S202111498016
6 · The paper itself

Abstract

<p>Background: Cinnamic acid and its derivatives have gained significant attention in recent medicinal research due to their broad spectrum of pharmacological properties. However, the effects of these compounds on xanthine oxidase (XO) have not been systematically investigated, and the inhibitory mechanism remains unclear. <p> Objectives: The objective of this study was to screen 18 compounds and identify the XO inhibitor with the strongest inhibitory effect. Furthermore, we aimed to study the inhibitory mechanism of the identified compound. <p> Methods: The effects of the inhibitors on XO were evaluated using kinetic analysis, docking simulations, and

Indexed as

HyperuricemiaXanthine OxidaseAnimalsEnzyme InhibitorsKineticsMiceMolecular Docking SimulationUric AcidEnzyme InhibitorsUric AcidXanthine Oxidase4-nitrocinnamic acidcinnamic acidderivativeshyperuricemia.uric acidXanthine oxidase

Identifiers

PMID37345239
OpenAlexW4381597671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.