Evidence map›Paper›PMID 37345228›Full record

ArticleCell transplantation

Ubiquitous Luciferase Expression in "Firefly Rats" Does Not Alter the Pancreatic Islet Morphology, Metabolism, and Function.

Nelson Gonzalez, Hiroyuki Kato, Wilma Tixi, Jose Ortiz, Chris Orr, Hung-Ping Shih, Hsun Teresa Ku, Jiing-Kuan Yee, Fouad Kandeel, Yoko Mullen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Nelson GonzalezDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Hiroyuki KatoDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Wilma TixiDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Jose OrtizDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Chris OrrDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Hung-Ping ShihDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Hsun Teresa KuDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Jiing-Kuan YeeDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Fouad KandeelDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Yoko MullenDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Eiji KobayashiDepartment of Kidney Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Hirotake KomatsuDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0003-0876-4809
City Of Hope National Medical Center · USJikei University School of Medicine · JP

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Microenvironmental cues control pancreas cell fate and beta-cell maturationR01DK119590 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHIH, HUNG-PING · 2018 to 2022
$2.1M
Vascular network-mimetic oxygen-transporting mesh for islet graftR03DK129958 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI KOMATSU, HIROTAKE · 2021 to 2022
$353k
NCI NIH HHS P30 CA033572NIDDK NIH HHS R01 DK119590NIDDK NIH HHS R03 DK129958
6 · The paper itself

Abstract

"Firefly rats" ubiquitously express the luciferase reporter gene under the control of constitutively active

Indexed as

Islets of LangerhansIslets of Langerhans TransplantationAnimalsBlood GlucoseFirefliesGlucoseInsulinLuciferasesRatsRats, Inbred LewBlood GlucoseGlucoseInsulinLuciferasesFirefly ratsin vivo imagingislet transplantationluciferaseluciferase reporter gene

Identifiers

PMID37345228
PMCPMC10328002
OpenAlexW4381598619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.